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首页> 外文期刊>International Journal of Experimental Pathology >Erythropoietin is involved in angiogenesis in human primary melanoma.
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Erythropoietin is involved in angiogenesis in human primary melanoma.

机译:促红细胞生成素参与人类原发性黑色素瘤的血管生成。

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摘要

In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis and tumour thickness. These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis.
机译:在这项研究中,在人类原发性黑素瘤标本中,以微血管体积密度,肿瘤细胞对促红细胞生成素(Epo)和内皮细胞对Epo受体(EpoR)的免疫反应性评估血管生成程度。结果表明,Epo / EpoR表达与血管生成和肿瘤厚度相关。这些发现表明,Epo由肿瘤细胞分泌,并通过其受体影响血管内皮细胞并以旁分泌方式促进血管生成,在黑色素瘤血管生成中起重要作用。

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