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首页> 外文期刊>International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience >Sexual differences in long-term effects of prenatal chronic mild stress on anxiety-like behavior and stress-induced regional glutamate receptor expression in rat offspring
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Sexual differences in long-term effects of prenatal chronic mild stress on anxiety-like behavior and stress-induced regional glutamate receptor expression in rat offspring

机译：产前慢性轻度应激对大鼠后代焦虑样行为和应激诱导的区域谷氨酸受体表达的长期影响的性别差异

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摘要

Severe adverse life events during pregnancy may increase the risk of anxiety disorders in the offspring. Glutamate receptors are neurobiological targets in anxiety disorders. In this study, we investigated the effects of prenatal chronic mild stress (PCMS) on anxiety-like behavior by using elevated plus maze (EPM), and evaluated the effects of PCMS and/or anxiogenic challenge on glutamate receptors in different brain regions. Our results showed that PCMS increased anxiety-like behavior in both male and female offspring. Moreover, compared with the male naive rats, male EPM rats showed a significant reduction of mGluR2/3 in the prefrontal cortex, mGluR1 and mGluR2/3 in the hippocampus, and increments of mGluR5, NR1, NR2B and PSD95 in the amygdala. In contrast, compared with female naive rats, female EPM rats showed decreased levels of mGluR5 in the hippocampus, and mGluR2/3 and mGluR5 in the prefrontal cortex, and increased levels of NR2B and PSD95 in the amygdala. Furthermore, PCMS seemed not to affect the baseline expression of glutamate receptors in adult offspring, but induced significant alterations of them triggered by anxiogenic challenge with a sex difference. These data strengthen the pathophysiological hypothesis that prenatal stress as a risk factor involves in the development of anxiety disorder in the offspring. (C) 2015 Published by Elsevier Ltd. on behalf of ISDN.
机译：怀孕期间严重的不良生活事件可能会增加后代出现焦虑症的风险。谷氨酸受体是焦虑症的神经生物学靶标。在这项研究中，我们通过使用高架迷宫（EPM）研究了产前慢性轻度应激（PCMS）对焦虑样行为的影响，并评估了PCMS和/或焦虑症对不同大脑区域谷氨酸受体的影响。我们的结果表明，PCMS可增加雄性和雌性后代的焦虑样行为。此外，与幼稚雄性大鼠相比，雄性EPM大鼠在前额叶皮层中的mGluR2 / 3显着减少，在海马中显示mGluR1和mGluR2 / 3显着减少，在杏仁核中mGluR5，NR1，NR2B和PSD95显着增加。相反，与雌性幼稚大鼠相比，雌性EPM大鼠海马中的mGluR5水平降低，前额叶皮层中的mGluR2 / 3和mGluR5水平降低，杏仁核中的NR2B和PSD95水平升高。此外，PCMS似乎不影响成年后代中谷氨酸受体的基线表达，但诱导了由性别差异引起的焦虑引起的显着改变。这些数据加强了病理生理学假设，即产前压力是一种危险因素，其参与了后代焦虑症的发展。 （C）2015由Elsevier Ltd.代表ISDN发布。

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