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首页> 外文期刊>British journal of ophthalmology >Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis.
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Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis.

机译：葡萄膜炎患者房水中色素上皮衍生因子与单核细胞趋化蛋白-1水平呈正相关。

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AIM: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. METHODS: Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples. RESULTS: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) microg/ml vs 5.01 (0.92) microg/ml vs 1.32 (0.22) microg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01). CONCLUSION: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.
机译：目的：评估葡萄膜炎患者房水中色素上皮衍生因子（PEDF）的水平是否与单核细胞趋化蛋白-1（MCP-1）相关。方法：采用ELISA法测定34例葡萄膜炎样本和9例白内障对照样本的MCP-1和PEDF的房水水平。结果：感染性或非感染性葡萄膜炎患者的房水MCP-1和PEDF水平显着高于对照组（平均值（标准差）32.3（10.7）ng / ml对4.48（1.10）ng / ml对0.47（0.10） ng / ml和8.40（1.30）microg / ml对5.01（0.92）microg / ml对1.32（0.22）microg / ml，p <0.001）。葡萄膜炎患者的PEDF与MCP-1之间呈正相关（r = 0.39，p <0.01）。结论：结果表明葡萄膜炎患者PEDF的房水水平与MCP-1呈正相关。目前的观察表明，PEDF的房水水平可能是葡萄膜炎炎症的标志。

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