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首页> 外文期刊>International journal of gynecological cancer: official journal of the International Gynecological Cancer Society >Incidence and risk factors of lower-extremity lymphedema after radical surgery with or without adjuvant radiotherapy in patients with FIGO stage I to stage IIA cervical cancer.
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Incidence and risk factors of lower-extremity lymphedema after radical surgery with or without adjuvant radiotherapy in patients with FIGO stage I to stage IIA cervical cancer.

机译：FIGO I期至IIA期宫颈癌患者接受或不接受辅助放疗的根治性手术后下肢淋巴水肿的发生率和危险因素。

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This study aimed to determine the incidence and risk factors of lower-extremity lymphedema (LEL) in women who had radical surgery with or without adjuvant radiotherapy for International Federation of Gynecology and Obstetrics (FIGO) stage I to stage IIA cervical cancer.The medical records were reviewed retrospectively on patients with histologically confirmed FIGO stage I to IIA cervical cancer. Lower-extremity lymphedema-related medical problems such as peripheral vascular disease, congestive heart failure, or chronic renal disease were excluded. A logistic regression analysis was used to examine the relationship between variable clinical characteristics and development of LEL.We evaluated 707 patients. Of the 707 patients evaluated, we excluded 92 patients who had received radiotherapy as the initial therapy and 19 patients with LEL related to medical problems. Seventy-five patients (12.6%) developed LEL. The incidence was high in patients with adjuvant radiotherapy (odds ratio, 3.47; 95% confidence interval, 2.086-5.788; P = 0.000), with 78.7% of the patients with LEL having developed the condition within 3 years after initial treatment.Adjuvant radiotherapy was significantly associated with development of LEL in women who had undergone radical surgery with lymphadenectomy for FIGO stage I to stage IIA cervical cancer. The possibility for the occurrence of LEL must be fully explained before treatment and patients should be provided with the appropriate preventive education. Further prospective studies are needed to confirm the incidence and risk factors for LEL.
机译：这项研究旨在确定国际妇产科联合会（FIGO）I期至IIA期宫颈癌的接受或不接受辅助放疗的根治性手术妇女下肢淋巴水肿（LEL）的发生率和危险因素。对组织学证实为FIGO I至IIA期宫颈癌的患者进行回顾性回顾。下肢淋巴水肿相关的医学问题，例如外周血管疾病，充血性心力衰竭或慢性肾脏疾病，被排除在外。采用logistic回归分析检查了临床特征与LEL发生之间的关系。我们评估了707例患者。在所评估的707例患者中，我们排除了92例接受放射疗法作为初始疗法的患者和19例与内科疾病相关的LEL患者。七十五名患者（12.6％）发生了LEL。辅助放疗的发生率很高（奇数比为3.47; 95％的置信区间为2.086-5.788; P = 0.000），其中78.7％的LEL患者在初次治疗后3年内就出现了这种状况。在接受FIGO I期至IIA期宫颈癌根治性手术的女性中，LEL的发生与LEL的发生显着相关。在治疗前必须充分解释发生LEL的可能性，并应为患者提供适当的预防教育。需要进一步的前瞻性研究以确认LEL的发生率和危险因素。

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