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首页> 外文期刊>Biochemical Genetics >Parallel Evolution of the Glycogen Synthase 1 (Muscle) Gene Gys1 Between Old World and New World Fruit Bats (Order: Chiroptera)
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Parallel Evolution of the Glycogen Synthase 1 (Muscle) Gene Gys1 Between Old World and New World Fruit Bats (Order: Chiroptera)

机译:旧世界和新世界水果蝙蝠之间糖原合酶1(肌肉)基因Gys1的平行进化(顺序:Chiroptera)

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摘要

Glycogen synthase, which catalyzes the synthesis of glycogen, is especially important for Old World (Pteropodidae) and New World (Phyllostomidae) fruit bats that ingest high-carbohydrate diets. Glycogen synthase 1, encoded by the Gys1 gene, is the glycogen synthase isozyme that functions in muscles. To determine whether Gys1 has undergone adaptive evolution in bats with carbohydrate-rich diets, in comparison to insect-eating sister bat taxa, we sequenced the coding region of the Gys1 gene from 10 species of bats, including two Old World fruit bats (Pteropodidae) and a New World fruit bat (Phyllostomidae). Our results show no evidence for positive selection in the Gys1 coding sequence on the ancestral Old World and the New World Artibeus lituratus branches. Tests for convergent evolution indicated convergence of the sequences and one parallel amino acid substitution (T395A) was detected on these branches, which was likely driven by natural selection.
机译:糖原合成酶催化糖原的合成,对于摄入高碳水化合物饮食的旧大陆(翼足类)和新大陆(蝙蝠科)果蝠尤其重要。由Gys1基因编码的糖原合酶1是在肌肉中起作用的糖原合酶同工酶。为了确定Gys1是否在富含碳水化合物饮食的蝙蝠中经历了适应性进化,与以昆虫为食的蝙蝠类群相比,我们对10种蝙蝠中Gys1基因的编码区进行了测序,其中包括两种旧世界水果蝙蝠(翼手龙)和新世界的水果蝙蝠(Phyllostomidae)。我们的结果表明,没有证据表明在祖先的旧世界和新世界的Artibeus lituratus分支上的Gys1编码序列中有阳性选择。收敛进化的测试表明序列的收敛,并且在这些分支上检测到一个平行的氨基酸取代(T395A),这很可能是自然选择所致。

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