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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation.
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p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation.

机译：通过X射线或碳离子束照射，p53依赖的高温增强肿瘤生长抑制作用。

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摘要

To elucidate p53-dependency on combined treatment with radiation and hyperthermia, growth inhibition and apoptosis were analysed using transplantable human tumour. Human head and neck squamous cell carcinoma (HNSCC) cells carrying different p53 genes were transplanted into the thigh of nude mice. When the mean diameter of tumour reached 5-6 mm, the tumours were exposed to X-rays (2 Gy) or Carbon-ion (C-) beams (1 Gy) followed by heating at 42 degrees C for 20 min. Tumour growth inhibition was evaluated by measuring the diameters of tumour. The induction of apoptosis and accumulation of apoptosis-related proteins were also analysed by immunohistochemical staining. Synergistic enhancement of tumour growth inhibition by hyperthermia was observed in wild-type p53 tumours treated with X-rays or C-beams but not in mutant p53 tumours. The incidence of apoptotic cells and activated-caspase-3-positive cells after combined treatment with them were significantly high in wild-type p53 tumours compared with that inmutant p53 tumours. The hyperthermic enhancement of tumour growth inhibition by X-ray- or C-beam-irradiation was p53-dependent, suggesting that it might be highly correlated with p53-dependent apoptosis.
机译：为了阐明p53对放疗和热疗联合治疗的依赖性，使用可移植的人类肿瘤分析了生长抑制和凋亡。携带不同p53基因的人头颈部鳞状细胞癌（HNSCC）细胞被移植到裸鼠的大腿中。当肿瘤的平均直径达到5-6 mm时，将肿瘤暴露于X射线（2 Gy）或碳离子（C-）射线（1 Gy）中，然后在42摄氏度加热20分钟。通过测量肿瘤直径来评估肿瘤生长抑制。还通过免疫组织化学染色分析了细胞凋亡的诱导和细胞凋亡相关蛋白的积累。在用X射线或C射线治疗的野生型p53肿瘤中观察到了热疗协同增强的肿瘤生长抑制作用，而在突变的p53肿瘤中则没有观察到。与不变的p53肿瘤相比，在野生型p53肿瘤中凋亡细胞和活化的caspase-3阳性细胞联合治疗后的发生率显着较高。 X射线或C射线照射对肿瘤生长抑制的高温增强是p53依赖性的，这表明它可能与p53依赖性凋亡高度相关。

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