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首页> 外文期刊>Biochemical Genetics >Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case-Control Study and Meta-analysis
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Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case-Control Study and Meta-analysis

机译：IGF2BP2，KCNJ11和CDKAL1多态性与摩洛哥人口中的2型糖尿病的关联分析：病例对照研究和荟萃分析

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Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
机译：对于不同人群中的变体CDKAL1 rs7756992，KCNJ11 rs5219和IGF2BP2 rs4402960，已确定与2型糖尿病的关联。在250名无关的摩洛哥糖尿病患者和250名健康对照组的病例对照研究中，我们使用TaqMan等位基因歧视试验对这三个SNP进行基因分型，并进行荟萃分析，以研究阿拉伯人群中多态性与糖尿病之间的关联。结果显示，仅在添加剂2（GG vs. TT; p = 0.009）和隐性模型（TT vs. GG + GT; p = 0.003）模型下，IGF2BP2基因的rs4402960显着与糖尿病显着相关。荟萃分析表明，IGF2BP2 rs4402960和CDKAL1 rs7756992多态性之间存在显着关联，并增加了阿拉伯人群患糖尿病的风险。根据我们的结果，病例对照研究和荟萃分析显示，摩洛哥和阿拉伯人群中IGF2BP2 rs4402960变异与2型糖尿病之间存在显着关联。

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