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首页> 外文期刊>International journal of gynecological pathology: Official journal of the International Society of Gynecological Pathologists >A pilot study of microsatellite instability and endometrial cancer survival in white and African American women.
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A pilot study of microsatellite instability and endometrial cancer survival in white and African American women.

机译：对白人和非裔美国人女性的微卫星不稳定性和子宫内膜癌生存率的初步研究。

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摘要

Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United States and can be classified on the basis of various pathologic, molecular, and genetic features, including microsatellite instability (MSI). As MSI is generally associated with a more favorable outcome in colorectal cancers, it is feasible that microsatellite instability may also influence endometrial cancer survival. We examined MSI and survival in 45 African American and 31 white women diagnosed with endometrial cancer at a large, urban cancer center. Fifty-five tumors were classified as type I and 21 tumors were classified as type II. Unconditional logistic regression models found that microsatellite stable tumors were more frequently observed in white women compared with African American women (odds ratio, 8.61; 95% confidence interval, 1.01-73.69). Type I tumors with MSI were not found to be significantly associated with smoking status, tumor stage, or age. Only one type II tumor was classified as MSI. Neither race nor MSI status was a predictor of death from all causes or only endometrial cancer-related deaths were considered in univariate and multivariate survival models. The potential significance of a larger proportion of MSI tumors found in African American women with type I endometrial cancer should be assessed in a larger prospective study.
机译：子宫内膜癌是美国最常见的妇科恶性肿瘤，可根据各种病理，分子和遗传特征（包括微卫星不稳定性（MSI））进行分类。由于MSI通常在结直肠癌中具有更好的预后，因此微卫星不稳定性也可能影响子宫内膜癌的生存是可行的。我们在一个大型城市癌症中心检查了45位被诊断患有子宫内膜癌的非洲裔美国人和31位白人女性的MSI和生存率。 55个肿瘤被分类为I型，而21个肿瘤被分类为II型。无条件逻辑回归模型发现，与非裔美国女性相比，白人女性更常观察到微卫星稳定肿瘤（优势比为8.61; 95％置信区间为1.01-73.69）。未发现患有MSI的I型肿瘤与吸烟状况，肿瘤分期或年龄显着相关。仅一种II型肿瘤被分类为MSI。在单变量和多变量生存模型中，种族和MSI状态均不能预测所有原因导致的死亡，或者仅考虑与子宫内膜癌相关的死亡。在一项较大的前瞻性研究中，应评估在患有I型子宫内膜癌的非洲裔美国女性中发现更大比例的MSI肿瘤的潜在意义。

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