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首页> 外文期刊>International journal of hematologic oncology. >Current and future immunotherapeutic approaches to multiple myeloma therapy
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Current and future immunotherapeutic approaches to multiple myeloma therapy

机译：当前和将来的多发性骨髓瘤治疗的免疫治疗方法

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Multiple myeloma (MM) is a hematologic malignancy associated with heterogeneous treatment and survival outcomes due in part to the ability of MM to evade and suppress the immune system. Research has focused on finding ways to modulate and enhance immunity while targeting the bone marrow microenvironment. Contemporary therapies include immunomodulatory drugs, proteasome inhibitors and autologous and allogeneic stem cell transplant and have improved outcomes for patients with MM. Future therapies, including monoclonal antibodies, chimeric antigen receptor cells and MM vaccines, show promise to further improved outcomes, particularly when used in combination with existing therapies. This review covers the mechanism of action of currently available and future therapies and explores ways in which treatment may be more specifically directed in the future.
机译：多发性骨髓瘤（MM）是一种血液恶性病，与异质性治疗和生存结果相关，部分原因是MM逃避和抑制免疫系统的能力。研究重点是寻找针对骨髓微环境的调节和增强免疫力的方法。当代疗法包括免疫调节药物，蛋白酶体抑制剂以及自体和同种异体干细胞移植，对MM患者的治疗效果有所改善。未来的疗法，包括单克隆抗体，嵌合抗原受体细胞和MM疫苗，有望进一步改善治疗效果，特别是与现有疗法联合使用时。这篇综述涵盖了目前可用和未来疗法的作用机制，并探讨了将来可能更具体地针对治疗的方法。

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