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首页> 外文期刊>International journal of immunogenetics >Association of interleukin-18 promoter polymorphisms with chronic obstructive pulmonary disease in male smokers.
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Association of interleukin-18 promoter polymorphisms with chronic obstructive pulmonary disease in male smokers.

机译：白细胞介素18启动子多态性与男性吸烟者慢性阻塞性肺疾病的关系。

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Chronic obstructive pulmonary disease (COPD) is considered a complex genetic disorder and it is expected that many genes play a role in the pathogenesis of this disease. Previous studies have reported that several variations within the interleukin (IL)-18 gene promoter region have been associated with different inflammatory diseases such as asthma. However, the association of IL-18 promoter polymorphisms with COPD has not been studied yet. We then performed a prospective case-control study to explore this association in male smokers of Chinese Han people. Our study recruited 112 COPD cases and 105 healthy controls matched for age. The genotyping of IL-18 promoter polymorphisms (-607 C/A and -137 G/C) was performed using TaqMan single nucleotide polymorphism genotyping assays. The frequencies of the alleles and genotypes in patients and controls were compared. We found that the frequency of IL-18 -607 C allele was significantly increased in patients with COPD (odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.01-2.15, P = 0.04). The frequency of IL-18 -607 C allele was significantly higher in the GOLD (Global initiative for Obstructive Lung Disease) 3-4 group compared with the GOLD 1-2 group (OR=2.06, 95% CI = 1.21-3.51, P = 0.01). There were no significant differences in the frequencies of the alleles and genotypes of IL-18 -137 G/C polymorphism between the patients and healthy smokers or between GOLD 3-4 group and GOLD 1-2 group. Our study revealed that the IL-18 -607 C/A polymorphism was associated with COPD susceptibility and severity of airflow limitation in male smokers of Chinese Han people.
机译：慢性阻塞性肺疾病（COPD）被认为是一种复杂的遗传疾病，预计许多基因在该疾病的发病机理中起作用。先前的研究报道了白介素（IL）-18基因启动子区域内的几种变异与不同的炎症性疾病如哮喘有关。然而，尚未研究IL-18启动子多态性与COPD的关联。然后，我们进行了一项前瞻性病例对照研究，以探讨中国汉族男性吸烟者中的这一关联。我们的研究招募了112名COPD病例和105名年龄匹配的健康对照者。 IL-18启动子多态性（-607 C / A和-137 G / C）的基因分型是使用TaqMan单核苷酸多态性基因分型分析进行的。比较了患者和对照组的等位基因频率和基因型。我们发现COPD患者中IL-18 -607 C等位基因的频率显着增加（几率（OR）= 1.48，95％置信区间（CI）= 1.01-2.15，P = 0.04）。与GOLD 1-2组相比，GOLD（全球阻塞性肺疾病倡议）3-4组的IL-18 -607 C等位基因频率显着更高（OR = 2.06，95％CI = 1.21-3.51，P = 0.01）。患者和健康吸烟者之间或GOLD 3-4组和GOLD 1-2组之间，IL-18 -137 G / C多态性的等位基因频率和基因型无明显差异。我们的研究表明，IL-18 -607 C / A基因多态性与中国汉族男性吸烟者的COPD敏感性和气流受限的严重程度有关。

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