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首页> 外文期刊>International journal of immunogenetics >A novel HLA-B allele, B*58:01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method
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A novel HLA-B allele, B*58:01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method

机译:使用基于序列的分型方法在台湾志愿者骨髓干细胞供体中检测到一种新型HLA-B等位基因B * 58:01:12

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摘要

Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.
机译:通过SBT(基于序列的分型)方法在台湾志愿者骨髓供体中发现了人类白细胞抗原-B * 58:01:12,这是一种新型的罕见HLA-B * 58:01变体等位基因。 B * 58:01:12的DNA序列与外显子2、3和4中的B * 58:01:01的序列相同,除了核苷酸位置483(其中核苷酸C被T取代)(密码子137; GAC GAT) )。由于沉默点突变,B * 58:01:12的氨基酸序列与B * 58:01:01的序列相同。与B * 58:01:12关联的HLA单倍型可以推导为A * 33:03-B * 58:01:12-DRB1 * 03:01。 B * 58:01:12的发现在台湾人口中进一步增加了B * 58:01的多态性。

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