...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil.
【24h】

TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil.

机译：巴西南部和东南部的TNF，IFNG，IL6，IL10和TGFB1基因多态性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study attempted to establish single nucleotide polymorphism frequencies of TNF, IL6, IFNG, IL10 and TGFB1 genes among healthy individuals from South and Southeast Brazil. The sample included 108 healthy individuals from South and 106 from Southeast Brazil. Polymerase chain reaction using sequence-specific primers genotyping was performed for these gene cytokines with Cytokine Genotyping Primers (One Lambda, Canoga Park, CA, USA). Differences in genotypic and allelic frequencies between the populations were assessed by chi-square with either Yates' correction or Fisher's exact test. Our investigations showed that there were not any significant differences between these two Brazilian populations for these polymorphisms. A statistically significant difference in the distribution of alleles and genotypes for both IL6 and IL10 genes was observed between the Brazilian population and the African-derived populations. IL6-174GG genotype and allele G and IL10-819CT/-592CA genotypes are more frequent in African-derived populations than in this mixed Brazilian population, while IL10-1082GG genotype is more frequent in our population. This mixed Brazilian population is closer to those of Joinville's, Santa Catarina, and Rio de Janeiro's, Rio de Janeiro (RJ), Euro-Brazilian populations than to those of Salvador's, Bahia, and Rio de Janeiro's, RJ, African-Brazilian populations. These findings have an enormous importance for experimental design and empowering future linkage and association mapping studies of the role of cytokines in human diseases and allotransplantation outcome in Brazil.
机译：这项研究试图建立巴西南部和东南部健康个体中TNF，IL6，IFNG，IL10和TGFB1基因的单核苷酸多态性频率。样本包括来自南部的108位健康个体和来自巴西东南部的106位健康个体。使用细胞因子基因分型引物（One Lambda，Canoga Park，CA，USA）对这些基因细胞因子进行了使用序列特异性引物的基因分型的聚合酶链反应。人群之间基因型和等位基因频率的差异通过卡方检验（采用Yates校正或Fisher精确检验）进行评估。我们的研究表明，在这两个巴西人之间，这些多态性没有任何显着差异。在巴西人群和非洲人群之间，IL6和IL10基因的等位基因和基因型分布在统计学上有显着差异。与非洲混合人群相比，非洲人群中的IL6-174GG基因型，等位基因G和IL10-819CT / -592CA基因型更为频繁，而在我们的人群中，IL10-1082GG基因型更为频繁。与巴西的萨尔瓦多，巴伊亚和里约热内卢的巴西和非洲人口相比，巴西的这种混合人口更接近于Joinville的圣卡塔琳娜州和里约热内卢，里约热内卢（RJ），欧洲巴西人口。这些发现对于实验设计和赋予未来对细胞因子在巴西人类疾病中的作用和同种异体移植结果的联系和关联作图研究的研究至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号