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首页> 外文期刊>International journal of hematologic oncology. >Prognostic factors in chronic lymphocytic leukemia: a conceptual approach
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Prognostic factors in chronic lymphocytic leukemia: a conceptual approach

机译：慢性淋巴细胞白血病的预后因素：一种概念方法

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Prognostic assessment is an essential component in the management of patients with chronic lymphocytic leukemia. Prognostic factors (e.g., clinical stage, lymphocyte doubling time and /GHUmutational status/ZAP70 expression), allow predicting time to disease progression and need of therapy and also provide a rough estimate of the overall survival. The most important predictor of survival in patients requiring intervention is response to therapy and its degree, patients with undetectable minimal residual disease following therapy having a much better outcome than those with an inferior response. Given the increasing number of treatment modalities for CLL, the identification of predictive factors is important. Unfortunately, with the only exception of del(17p)/TP53 mutations that predict a poor response to purine analogs-based therapy and del(11cp that correlates with inferior response to fludarabine given as single agent, there are not reliable predictors of response. Well-conducted studies aimed at identifying prognostic and, particularly, predictive factors are needed. New prognostic and predictive parameters should demonstrate superiority over already well validated markers and be helpful in the management of patients with CLL
机译：预后评估是慢性淋巴细胞性白血病患者管理中的重要组成部分。预后因素（例如临床阶段，淋巴细胞加倍时间和/ GHUmutational status / ZAP70表达）可以预测疾病进展时间和治疗需求，还可以粗略估算总体生存率。需要干预的患者中生存的最重要预测指标是对治疗及其程度的反应，治疗后无法检测到极少残留病的患者的疗效要比反应较差的患者好得多。鉴于CLL的治疗方式越来越多，确定预测因素非常重要。不幸的是，除了del（17p）/ TP53突变预测对基于嘌呤类似物的治疗反应较差和del（11cp与单药对氟达拉滨的反应较差有关）之外，没有可靠的反应预测因子。进行旨在确定预后因素，尤其是预测因素的研究，新的预后和预测参数应证明优于已经有效验证的标志物，并有助于CLL患者的治疗

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