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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Determination of the temperature-dependent electric conductivity of liver tissue ex vivo and in vivo: Importance for therapy planning for the radiofrequency ablation of liver tumours.
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Determination of the temperature-dependent electric conductivity of liver tissue ex vivo and in vivo: Importance for therapy planning for the radiofrequency ablation of liver tumours.

机译：体外和体内测定肝脏组织的温度依赖性电导率：对于肝肿瘤射频消融治疗计划的重要性。

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Introduction: Knowledge about the changes in the electric conductivity during the coagulation process of radiofrequency ablation of the liver is a prerequisite for the predictability of produceable thermonecrosis in the liver. Materials and methods: Continuous measurements of the electric conductivity sigma in ex vivo porcine liver (n = 25) were done during the coagulation and cooling process at the temperature range of the radiofrequency ablation at a frequency of 470 kHz relevant for the radiofrequency ablation. Measurements of the electric conductivity were performed in both perfused porcine liver (n = 3) and a human surgical specimen from a colorectal liver metastasis. Results: At a body temperature of 37 degrees C, conductance sigma was 0.41 siemens per metre (0.32 S/m; 0.52 S/m). Conductance sigma increased continuously and uniformly at a temperature of 77 degrees C. Maximum conductance sigma with 0.79 S/m (0.7 S/m; 0.87 S/m) was reached at 80 degrees C. A continuous reduction of conductance was observed during the cooling phase. At 37 degrees C, the specific conductance sigma in the healthy perfused porcine liver was 0.52 S/m, 0.55 S/m and 0.57 S/m (mean 0.55 S/m). The electric conductivity of the human colorectal liver metastasis was clearly higher. Conclusion: Changes in the specific conductivity during the coagulation and the cooling phase play an important role for the produceable size of a coagulation necrosis and necessitates an adaptation of the therapy parameters during radiofrequency ablation.
机译：简介：了解肝脏射频消融凝结过程中电导率的变化是可预测肝脏可发生热坏死的前提。材料和方法：在凝结和冷却过程中，在射频消融的温度范围内，以与射频消融相关的470 kHz频率，对离体猪肝脏（n = 25）的电导率sigma进行连续测量。在灌注的猪肝脏（n = 3）和来自结直肠肝转移的人类手术标本中均进行了电导率的测量。结果：在37摄氏度的体温下，电导率sigma为0.41西门子/米（0.32 S / m; 0.52 S / m）。电导率σ在77摄氏度的温度下连续且均匀地增加。在80摄氏度时达到0.79 S / m（0.7 S / m; 0.87 S / m）的最大电导率σ。在冷却过程中观察到电导率连续降低相。在37摄氏度时，健康的灌注猪肝中的比电导率sigma为0.52 S / m，0.55 S / m和0.57 S / m（平均0.55 S / m）。人结肠直肠肝转移的电导率明显更高。结论：凝结和冷却阶段电导率的变化对于凝结坏死的可产生大小起着重要作用，并且在射频消融期间必须调整治疗参数。

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