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首页> 外文期刊>British journal of ophthalmology >Clinical characteristics of Mooren's ulcer in South India.
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Clinical characteristics of Mooren's ulcer in South India.

机译：印度南部Mooren溃疡的临床特征。

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AIM: To describe the clinical characteristics at presentation of a large cohort of patients with Mooren's ulcer in South India. METHODS: The medical records of patients with Mooren's ulcer examined in the cornea clinic at Aravind Eye Hospital Madurai, Tamil Nadu, India, over a 10-year period were reviewed in this retrospective observational case series. RESULTS: The cohort contained 242 eyes of 166 patients. All patients were from South India, and men outnumbered women by a ratio of 4.7:1. The median and mean ages at presentation were 65 and 61 years, respectively, with a range of 13-95 years. One eye was affected in 90 of 166 (54%) patients. Visual acuity in the affected eye at presentation ranged from 6/6 to light perception, and was 6/12 or better in 34 of 242 (14%) eyes, between 6/12 and 3/60 in 168 (69%) eyes, and worse than 3/60 in 40 (17%) eyes. Partial peripheral corneal ulceration was observed in 222 (92%) eyes, complete peripheral corneal ulceration was observed in 15 (6%) eyes and total corneal ulceration was observed in 5 (2%) eyes. For those 222 eyes with partial peripheral ulceration, 152 (68%) showed temporal involvement, 129 (58%) showed nasal involvement, 116 (52%) showed inferior involvement and 30 (14%) showed superior involvement. Perforation was observed in 26 (11%) eyes, and was more common in eyes with peripheral as compared with total ulceration (p<0.001). Identified risk factors in the cohort included evidence of prior corneal surgery (22%), corneal trauma (17%) and corneal infection (2%). CONCLUSIONS: Mooren's ulcer is a rare and potentially blinding eye condition observed not infrequently in the cornea clinic at Aravind Eye Hospital. Men are affected more often than women and may present with either unilateral or bilateral disease. Perforation is observed in approximately 1 in 10 affected eyes at presentation and occurs most often in the setting of peripheral ulceration. The occurrence of prior corneal surgery, trauma or infection in nearly one third of patients supports theories of exposure to corneal antigen in the pathogenesis of this disorder.
机译：目的：描述印度南部一大批患有Mooren溃疡的患者的临床特征。方法：本回顾性观察病例系列回顾了在印度泰米尔纳德邦马杜赖市Aravind眼医院的角膜诊所检查的Mooren溃疡患者的病历10年。结果：该队列包含166例患者的242眼。所有患者均来自印度南部，男性比女性多4.7：1。报告时的中位年龄和平均年龄分别为65岁和61岁，范围为13-95岁。 166位患者中的90位（54％）患了一只眼睛。患眼呈现时的视敏度从6/6到光线感知不等，在242眼（14％）的34眼中为6/12或更高，在168眼（69％）的6/12至3/60之间，在40（17％）眼中比3/60差。在222（92％）眼中观察到部分外周角膜溃疡，在15（6％）眼中观察到完全外周角膜溃疡，在5（2％）眼中观察到全部角膜溃疡。在222眼部分周围溃疡中，有152例（68％）表现为颞侧受累，有129例（58％）表现为鼻腔受累，有116例（52％）表现为下眼受累，其中30眼（14％）表现为上眼受累。在26只眼（11％）眼中观察到穿孔，与全溃疡相比，在有外周眼的眼中更常见（p <0.001）。队列中确定的危险因素包括先前进行过角膜手术（22％），角膜外伤（17％）和角膜感染（2％）的证据。结论：Mooren's溃疡是一种罕见且可能致盲的眼部疾病，在Aravind眼科医院的角膜诊所中很少见到。与女性相比，男性受到的影响更大，并且可能患有单侧或双侧疾病。在出现时，大约每10个受影响的眼睛中就有1个出现穿孔，最常发生在周围性溃疡的发生中。在近三分之一的患者中发生了先前的角膜手术，创伤或感染，这支持了在这种疾病的发病机理中接触角膜抗原的理论。

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