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首页> 外文期刊>International journal of immunogenetics >HLA-A, HLA-B, HLA-DRB1 allele and haplotype frequencies of 14529 Chinese Han bone marrow donors living in Dalian, China
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HLA-A, HLA-B, HLA-DRB1 allele and haplotype frequencies of 14529 Chinese Han bone marrow donors living in Dalian, China

机译：居住在中国大连的14529名中国汉族骨髓供者的HLA-A，HLA-B，HLA-DRB1等位基因和单倍型频率

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摘要

We investigated the allele and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 loci in Dalian Chinese Han population using blood samples of unrelated marrow donors who live in Dalian. The genetic relationship between Dalian and different regions worldwide was further explored based on HLA status of different populations. A total of 14529 samples were genotyped at 2-digit level only by sequence-specific oligonucleotide and sequence-based typing methods. Allele frequencies of HLA-A, HLA-B and HLA-DRB1 were calculated by the direct counting method. Haplotype frequencies and linkage disequilibrium (LD) values were calculated by the maximum likelihood method. F-ST values were calculated by allele frequency data of each locus. Phylogeny tree of Nei's D-A genetic distances was constructed by the UPGMA method. HLA-A*02 was the most frequent allele at HLA-A locus followed by A*11 and A*24. Alleles at HLA-B locus ranked in decreasing order by frequency were B*40, B*15 and B*13. The three highest frequency alleles were DRB1*15, DRB1*09 and DRB1*12 at HLA-DRB1 locus. A*30-B*13-DRB1*07 was the most frequent three-locus haplotype. For the population relationships, Dalian had a relative close genetic relationship with Liaoning and Yantai-Weihai and a relative distant genetic relationship with Australia. The information obtained in this study may provide useful information for anthropological studies, for disease-association studies and helping bone marrow transplantation patients to search HLA-matched donors.
机译：我们使用居住在大连的无关骨髓供体的血液样本调查了大连中国汉族人群中HLA-A，HLA-B和HLA-DRB1基因座的等位基因和单倍型频率。根据不同人群的HLA状况，进一步探讨了大连与全球不同地区之间的遗传关系。仅通过序列特异性寡核苷酸和基于序列的分型方法对总共14529个样品进行了2位数字的基因分型。通过直接计数法计算HLA-A，HLA-B和HLA-DRB1的等位基因频率。通过最大似然法计算单体型频率和连锁不平衡（LD）值。通过每个基因座的等位基因频率数据计算F-ST值。利用UPGMA方法构建了Nei D-A遗传距离的系统树。 HLA-A * 02是HLA-A位点最常见的等位基因，其次是A * 11和A * 24。 HLA-B基因座的等位基因按频率降序排列为B * 40，B * 15和B * 13。在HLA-DRB1位点，三个频率最高的等位基因为DRB1 * 15，DRB1 * 09和DRB1 * 12。 A * 30-B * 13-DRB1 * 07是最常见的三位点单倍型。就人口关系而言，大连与辽宁和烟台-威海有较近的遗传关系，与澳大利亚则有较远的遗传关系。从这项研究中获得的信息可能为人类学研究，疾病关联研究以及帮助骨髓移植患者寻找HLA匹配的供体提供有用的信息。

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