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首页> 外文期刊>International journal of immunogenetics >An important role for autoimmunity in the immunopathogenesis of chronic allograft rejection.
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An important role for autoimmunity in the immunopathogenesis of chronic allograft rejection.

机译：自身免疫在慢性同种异体移植排斥反应的免疫发病机制中的重要作用。

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摘要

Organ transplantation is the treatment of choice for patients with end-stage organ dysfunction. In spite of advances in understanding of donor and recipient physiology, organ preservation, operative techniques and immunosuppression, long-term graft survival still remains a major problem primarily due to chronic rejection. Alloimmune responses to mismatched major histocompatibility antigens have been implicated as an important factor leading to rejection. However, there is increasing evidence pointing towards cross-talk between the alloimmune and autoimmune responses creating a local inflammatory milieu, which eventually leads to fibrosis and occlusion of the lumen in the transplanted organ i.e. chronic rejection. In this review, we will discuss recent studies and emerging concepts for the interdependence of alloimmune and autoimmune responses in the immunopathogenesis of chronic allograft rejection. The role of autoimmunity in the development of chronic rejection is an intriguing and exciting area of research in the field of solid-organ transplantation with a significant potential to develop novel therapeutic strategies towards preventing chronic allograft rejection.
机译：器官移植是终末期器官功能障碍患者的首选治疗方法。尽管在了解供体和受体的生理学，器官保存，手术技术和免疫抑制等方面已有进展，但长期移植物的存活仍然是主要的问题，这主要是由于慢性排斥。对失配的主要组织相容性抗原的同种免疫反应被认为是导致排斥反应的重要因素。然而，越来越多的证据表明，同种免疫和自身免疫反应之间存在相互干扰，从而产生局部炎症环境，最终导致移植器官内纤维化和管腔阻塞，即慢性排斥。在这篇综述中，我们将讨论慢性同种异体移植排斥反应的免疫发病机制中同种免疫和自身免疫反应的相互依赖性的最新研究和新兴概念。自身免疫在慢性排斥反应发展中的作用是固体器官移植领域中一个有趣而令人兴奋的研究领域，具有开发预防慢性同种异体移植排斥反应的新治疗策略的巨大潜力。

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