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首页> 外文期刊>Biochemical Genetics >Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.
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Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.

机译：土耳其人群中磺基转移酶（SULT1A1和SULT1A2）的遗传多态性。

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摘要

Sulfotransferases (SULTs) play a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds. SULTs are genetically polymorphic enzymes; to date, 12 human cytosolic SULT isoforms have been identified. This study investigated SULT1A1 and SULT1A2 gene polymorphism using a PCR-RFLP method (n = 303). The frequency of the SULT1A1*1 allele was 76.2% and SULT1A1*2 was 23.8%. The SULT1A1*3 allele could not be identified. The SULT1A2 frequencies were 69.2% (SULT1A2*1), 18.3% (SULT1A2*2), and 12.5% (SULT1A2*3). The SULT1A1 and SULT1A2 loci were in Hardy-Weinberg equilibrium (SULT1A1 chi(2) = 0.58, P = 0.44; SULT1A2 chi(2) = 7.28, P = 0.06). Linkage analysis indicated a close linkage between these two genes (chi(2) = 5.31, P < 0.01); therefore, the statistical hypothesis that SULT1A1 and SULT1A2 alleles are independently distributed was rejected. Additionally, a strongly positive linkage was detected between SULT1A1*2 and SULT1A2*2 alleles in this population (D' = 0.79, chi(2) = 33.33).
机译：磺基转移酶（SULTs）在多种异种生物和内源性化合物的生物转化中起重要作用。 SULT是遗传多态性酶。迄今为止，已经鉴定出12种人胞质SULT同工型。本研究使用PCR-RFLP方法（n = 303）研究了SULT1A1和SULT1A2基因多态性。 SULT1A1 * 1等位基因的频率为76.2％，SULT1A1 * 2等位基因为23.8％。无法识别SULT1A1 * 3等位基因。 SULT1A2频率为69.2％（SULT1A2 * 1），18.3％（SULT1A2 * 2）和12.5％（SULT1A2 * 3）。 SULT1A1和SULT1A2基因座处于Hardy-Weinberg平衡状态（SULT1A1 chi（2）= 0.58，P = 0.44; SULT1A2 chi（2）= 7.28，P = 0.06）。连锁分析表明这两个基因之间的紧密连锁（chi（2）= 5.31，P <0.01）;因此，拒绝了SULT1A1和SULT1A2等位基因独立分布的统计假设。此外，在此人群中，在SULT1A1 * 2和SULT1A2 * 2等位基因之间检测到强阳性连锁（D'= 0.79，chi（2）= 33.33）。

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