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首页> 外文期刊>International journal of immunogenetics >TNF promoter SNP variation in Amerindians and white-admixed women from Misiones, Argentina.
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TNF promoter SNP variation in Amerindians and white-admixed women from Misiones, Argentina.

机译：美洲印第安人和来自阿根廷米西奥内斯的白人混血妇女中的TNF启动子SNP变异。

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摘要

The aim of this study is to describe genetic variation in the TNF promoter in the ethnically diverse population of Misiones, north-eastern Argentina. We analysed 210 women including 66 Amerindians of the Mbya-Guarani ethnic group and 144 white-admixed individuals from urban and rural areas of Misiones. Their DNA samples were surveyed for TNF polymorphisms -376 A/G, -308 A/G -244 A/G and -238 A/G by PCR amplification and direct sequencing and for the Amerindian marker -857 C/T by real-time PCR. Our main findings are as follows:(i) a distinctive pattern of Single Nucleotide Polymorphism (SNP) distribution among these groups, (ii) genetic differentiation between the Mbya-Guarani and the white-admixed populations (P < 0.05), (iii) lower gene diversity (~0.05) in Mbya-Guarani compared with the white-admixed group (~0.21); and (iv) linkage disequilibrium between the -376A and -238A SNPs in white-admixed populations. These data highlight the principal role of population history in establishing present-day genetic variation at the TNF locus and provide a framework for undertaking ethnographic and disease association studies in Misiones.
机译：这项研究的目的是描述阿根廷东北部米西奥内斯（Misiones）不同种族的人群中TNF启动子的遗传变异。我们分析了210名妇女，包括66名姆比亚-瓜拉尼族的美洲印第安人和144名来自米西奥内斯城乡地区的白人混血人士。通过PCR扩增和直接测序对他们的DNA样品进行TNF多态性-376 A / G，-308 A / G -244 A / G和-238 A / G的检测，并通过实时检测美洲印第安人标记-857 C / T的多态性。 PCR。我们的主要发现如下：（i）这些人群中单核苷酸多态性（SNP）分布的独特模式，（ii）姆比亚瓜拉尼人与白人混居人群之间的遗传分化（P <0.05），（iii）与白色混血组相比，姆比亚瓜拉尼地区的基因多样性较低（〜0.05）（〜0.21）; （iv）在白色混合人群中-376A和-238A SNP之间存在连锁不平衡。这些数据突显了人口史在建立TNF基因座当今遗传变异中的主要作用，并为在米西奥内斯进行人种学和疾病关联研究提供了框架。

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