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首页> 外文期刊>International journal of immunogenetics >Association analysis of polymorphisms in OAS1 with susceptibility and severity of hand, foot and mouth disease
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Association analysis of polymorphisms in OAS1 with susceptibility and severity of hand, foot and mouth disease

机译：OAS1基因多态性与手足口病易感性和严重性的关联分析

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Summary: Hand, foot and mouth disease (HFMD) is a common childhood illness that mainly affects Asian children under the age of 5 years. Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the most common pathogens of HFMD. It is imperative that the susceptible population is screened early and that the severe illness population can be identified via genetic variation detection in children. Four single-nucleotide polymorphisms (SNP) [2'-5'-oligoadenylate synthetase1 (OAS1) rs10774671, selectin P ligand (SELPLG) rs2228315, scavenger receptor class B member 2 (SCARB2) rs41284767 and interleukin 28B (IL28B) rs12979860] were determined by Taqman assays in 333 HFMD samples and 163 control samples. The rs2228315, rs41284767 and rs12979860 polymorphisms did not differ significantly between HFMD patients and the controls, but the prevalence of the rs10774671 polymorphism was significantly different between the control children and children infected with CA16 (GG genotype vs. AA + AG genotype, P < 0.05). Children with the GG genotype were more susceptible to CA16-type HFMD. Furthermore, the rs10774671 genotype distribution was clearly different between children with severe HFMD and those with mild HFMD [P < 0.05, OR 0.240, 95% CI (0.071-0.809)]. HFMD children with the AA+AG genotype were more likely to progress to encephalitis than were those with the GG genotype. Plasma γ-interferon (IFN) expression levels among control children and the mild and severe HFMD children were detected by ELISA. Those with mild HFMD had higher γ-IFN expression levels compared with those with severe HFMD (P < 0.05). In addition, there is a significant correlation between γ-IFN levels and OAS1 rs10774671 SNP, as analysed by linear correlation assay. The GG genotype correlated with higher γ-IFN levels (P < 0.05). In short, the OAS1 rs10774671 SNP GG genotype contributed to CA16 susceptibility and was associated with the development of mild HFMD.
机译：简介：手足口病（HFMD）是一种常见的儿童疾病，主要影响5岁以下的亚洲儿童。人肠道病毒71（EV71）和柯萨奇病毒A16（CA16）是手足口病最常见的病原体。必须对易感人群进行早期筛查，并可以通过儿童的遗传变异检测来识别严重疾病人群。确定了四个单核苷酸多态性（SNP）[2'-5'-寡腺苷酸合成酶1（OAS1）rs10774671，选择素P配体（SELPLG）rs2228315，清道夫受体B类成员2（SCARB2）rs41284767和白介素28B（IL28B）rs12979860] Taqman分析法检测的333个HFMD样品和163个对照样品。 rs2228315，rs41284767和rs12979860多态性在手足口病患者和对照组之间没有显着差异，但在对照组和感染CA16的儿童中，rs10774671多态性的发生率显着不同（GG基因型与AA + AG基因型，P <0.05 ）。 GG基因型的儿童更容易患CA16型手足口病。此外，重度手足口病患儿和轻度手足口病患儿的rs10774671基因型分布明显不同[P <0.05，或0.240，95％CI（0.071-0.809）]。 AA + AG基因型的HFMD儿童比GG基因型的儿童更容易发展为脑炎。通过ELISA检测对照儿童以及轻度和重度手足口病儿童的血浆γ-干扰素（IFN）表达水平。轻度手足口病患者的γ-IFN表达水平高于重度手足口病患者（P <0.05）。此外，通过线性相关分析可知，γ-IFN水平与OAS1 rs10774671 SNP之间存在显着相关性。 GG基因型与较高的γ-IFN水平相关（P <0.05）。简而言之，OAS1 rs10774671 SNP GG基因型有助于CA16易感性，并与轻度手足口病的发展有关。

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