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首页> 外文期刊>International journal of immunogenetics >Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome.
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Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome.

机译：唐氏综合症患儿外周血T细胞亚群，自然杀伤细胞和血清细胞因子水平的分析。

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The objective of this study was to evaluate the relationship between humoral and cell-mediated immune response parameters and impairment of immune functions in children with Down syndrome (DS). The patient group was consisted of cytogenetically documented 32 children with DS. Lymphocyte subsets and natural killer cells were counted by flow-cytometry system. Levels of interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-alpha) were detected by enzyme-linked immunosorbent assay method. Serum IgG, IgM, IgA levels were measured by turbidimetric methods. The percentage of CD8+ lymphocytes and CD56+ cells of patients with DS were significantly higher, whereas CD20+ lymphocytes were lower than that of controls (P < 0.05). The percentage of CD2 and CD4 levels and CD4/CD8 ratio of patients with DS and normal controls were similar (P > 0.05). Levels of IL-4 and IL-10 were significantly increased, but IL-6 and TNF-alpha levels were decreased in children with DS (P < 0.05). Levels of other studied cytokines between patients with DS and controls were not statistically different (P > 0.05, for all). Serum IgG, IgM and IgA levels were found to be similar between the groups (P > 0.05). It has been known that IL-4 and IL-10 are anti-inflammatory molecules which inhibit the synthesis of proinflammatory cytokines such as IL-6 and TNF-alpha. In this study, levels of IL-4 and IL-10 were significantly increased, but IL-6 and TNF-alpha levels were decreased in children with DS. These results may suggest that continuing anti-inflammatory state in DS and this process may explain the cause of recurrent infection of the disease. On the other hand, in contrast to the low percentage of CD20+ cells, high percentage of CD8+ and CD56+ cells were found. Our findings may demonstrate that the cell-mediated and humoral immune system parameters in children with DS were altered according to healthy children.
机译：这项研究的目的是评估唐氏综合症（DS）儿童的体液和细胞介导的免疫反应参数与免疫功能受损之间的关系。患者组由细胞遗传学记录的32名DS患儿组成。通过流式细胞仪计数淋巴细胞亚群和自然杀伤细胞。通过酶联免疫吸附法检测白介素（IL）-1β，IL-2，IL-4，IL-6，IL-8，IL-10和肿瘤坏死因子-α（TNF-α）的水平。通过比浊法测量血清IgG，IgM，IgA水平。 DS患者的CD8 +淋巴细胞和CD56 +细胞的百分比明显高于对照组，而CD20 +淋巴细胞的百分比低于对照组（P <0.05）。 DS患者和正常对照者的CD2和CD4水平百分比以及CD4 / CD8比值相似（P> 0.05）。 DS患儿IL-4和IL-10水平显着升高，但IL-6和TNF-α水平降低（P <0.05）。 DS患者与对照组之间其他研究的细胞因子水平无统计学差异（对于所有患者，P> 0.05）。两组之间的血清IgG，IgM和IgA水平相似（P> 0.05）。已知IL-4和IL-10是抗炎分子，其抑制促炎细胞因子如IL-6和TNF-α的合成。在这项研究中，DS患儿的IL-4和IL-10水平显着升高，但IL-6和TNF-α水平降低。这些结果可能表明DS中持续的抗炎状态，并且该过程可以解释疾病反复感染的原因。另一方面，与低百分比的CD20 +细胞相反，发现高百分比的CD8 +和CD56 +细胞。我们的发现可能表明，DS患儿的细胞介导和体液免疫系统参数已根据健康儿童而改变。

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