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首页> 外文期刊>International journal of immunopathology and pharmacology. >Interferon-γ release assays for the diagnosis of mycobacterium tuberculosis infection in children: A systematic review and meta-analysis
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Interferon-γ release assays for the diagnosis of mycobacterium tuberculosis infection in children: A systematic review and meta-analysis

机译：γ-干扰素释放测定对儿童结核分枝杆菌感染的诊断：系统评价和荟萃分析

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摘要

Data regarding the use of Interferon-gamma release assays (IGRAs) for tuberculosis diagnosis are accumulating. We systematically searched PubMed, EMBASE and Cochrane and performed pooled estimates of sensitivity and specificity of QuantiFERON-TB Gold In Tube (QFT-G-IT) and T-SPOT. TB compared to tuberculin skin test (TST). For studies assessing sensitivity, children had to have active tuberculosis. Specificity data were derived from children classified as non-infected. Eleven studies were included in the sensitivity analysis for TST, 10 for QFT-G-IT, and 9 for T-SPOT.TB. Eight studies were included in specificity analysis for TST, 8 for QFT-G-IT, and 7 for T-SPOT.TB. Pooled QFT-GIT sensitivity was 0.79 (95%CI:0.70-0.89) pooled T-SPOT.TB sensitivity was 0.74 (95%CI:0.59-0.90) and pooled TST sensitivity was 0.82 (95%CI:0.72-0.93). Pooled QFT-G-IT and T-SPOT.TB specificities were 0.95 (95%CI:0.93- 0.97) and 0.96 (95%CI:0.93-1.00), respectively. Pooled TST specificity was significantly lower 0.83 (95%CI:0.74-0.92). IGRA performance in children showed no better sensitivity than TST, but higher specificity.
机译：有关使用干扰素-γ释放测定法（IGRA）进行结核病诊断的数据正在积累。我们系统地搜索了PubMed，EMBASE和Cochrane，并对QuantiFERON-TB管中金（QFT-G-IT）和T-SPOT的敏感性和特异性进行了汇总估计。结核病与结核菌素皮肤试验（TST）相比。为了进行敏感性研究，儿童必须患有活动性结核病。特异性数据来自分类为未感染的儿童。 TST敏感性分析包括11项研究，QFT-G-IT包括10项，T-SPOT.TB包括9项。 TST的特异性分析中包括八项研究，QFT-G-IT包括八项研究，T-SPOT.TB包括七项研究。合并的QFT-GIT敏感性为0.79（95％CI：0.70-0.89）合并的T-SPOT.TB敏感性为0.74（95％CI：0.59-0.90）和合并的TST敏感性为0.82（95％CI：0.72-0.93）。合并的QFT-G-IT和T-SPOT.TB特异性分别为0.95（95％CI：0.93- 0.97）和0.96（95％CI：0.93-1.00）。合并的TST特异性显着降低0.83（95％CI：0.74-0.92）。儿童的IGRA表现没有比TST更好的敏感性，但是特异性更高。

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