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首页> 外文期刊>International journal of immunogenetics >Solid-phase assays for the detection of alloantibody against human leukocyte antigens: Panacea or Pandora?
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Solid-phase assays for the detection of alloantibody against human leukocyte antigens: Panacea or Pandora?

机译：固相测定法可检测针对人类白细胞抗原的同种抗体：万能药或潘多拉菌？

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Summary: Serological assessments of antibodies directed against human leucocyte antigens (HLA) formed the basis of early histocompatibility testing (Patel & Terasaki, 1969 N Engl J Med, 280, 735). However, over the past decade, significant advances in HLA antibody detection technologies have emerged. The development and implementation of solid-phase assays has led to safer and more efficient allocation of organs by effectively distinguishing HLA from non-HLA antibodies. Although solid-phase assays are not standardized, they are widely accepted as the new 'gold standard'. However, this technology is not without its challenges. This review is intended to provide a better understanding of solid-phase HLA antibody testing and will focus on important caveats associated with this evolving technology. Examples of the limitations of the technology as well as common data misinterpretations will be shown. Both of which could pose potential harm to transplant recipients (Tait et al., Transplantation, 95, 19).
机译：简介：针对人类白细胞抗原（HLA）的抗体的血清学评估构成了早期组织相容性测试的基础（Patel＆Terasaki，1969 N Engl J Med，280，735）。但是，在过去的十年中，HLA抗体检测技术取得了重大进步。通过有效区分HLA和非HLA抗体，固相分析的开发和实施已导致更安全，更有效地分配器官。尽管固相测定尚未标准化，但它们被广泛接受为新的“金标准”。但是，这项技术并非没有挑战。这篇综述旨在提供对固相HLA抗体测试的更好理解，并将重点关注与此技术发展相关的重要警告。将显示技术限制以及常见数据误解的示例。两者都可能对移植接受者造成潜在伤害（Tait等，Transplantation，95，19）。

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