FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians.

Potaczek DP; Sanak M; Nishiyama C; Okumura K; Ogawa H; Szczeklik A

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FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians.

机译：高加索人和东亚人中FCER1A基因近端启动子多态性。

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Two FCER1A gene proximal promoter polymorphisms, -344C > T and -95T > C, both associated with total serum IgE and/or allergic disorders in Caucasians and East Asians, were shown to influence the gene expression in additive manner. In face of the rarity of other proximal promoter variants in Caucasians or their lack in East Asians, future investigations of the FCER1A locus in these ethnic groups should probably focus on three common haplotypes of the common -344C > T and -95T > C polymorphisms.

机译：两种FCER1A基因近端启动子多态性-344C> T和-95T> C，均与白种人和东亚人的总血清IgE和/或过敏性疾病相关，它们以累加方式影响基因表达。面对高加索人中其他近端启动子变体稀少或东亚人缺乏这种情况，在这些族裔中对FCER1A基因座的进一步研究可能应该集中在常见的-344C> T和-95T> C多态性的三种常见单倍型上。

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《International journal of immunogenetics》 |2008年第5期|共2页
作者
Potaczek DP; Sanak M; Nishiyama C; Okumura K; Ogawa H; Szczeklik A;
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正文语种 eng
中图分类基础医学;
关键词
Asian Continental Ancestry Group; European Continental Ancestry Group; Haplotypes; 单元型; 受体; IGE;

机译：Asian Continental Ancestry Group;European Continental Ancestry Group;Haplotypes;单元型;受体;IGE;

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1. FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians. [J] . Potaczek DP, Sanak M, Nishiyama C, International journal of immunogenetics . 2008,第4a5期

机译：高加索人和东亚人中FCER1A基因近端启动子多态性。
2. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. [J] . Vasseur F, Dina C, Delannoy V, Human Molecular Genetics . 2002,第21期

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3. Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population [J] . ZhouJ., ZhouY., LinL.-H., Human Immunology: Official Journal of the American Society for Histocompatibility and Immunogenetics . 2012,第3期

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7. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians [O] . F. Vasseur 2002

机译：在APM1基因的近端启动子和外显子3中的单核苷酸多态性单倍型调节脂肪细胞分泌的脂联素水平，并有助于法国高加索人的2型糖尿病的遗传风险
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FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians.

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