HLA antibody testing: a tool to facilitate not to prevent organ transplantation

Frans H. J. Claas

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HLA antibody testing: a tool to facilitate not to prevent organ transplantation

机译：HLA抗体测试：促进不预防器官移植的工具

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The introduction of very sensitive HLA antibody screening assays has destroyed the old dogma that pre-existence of donor specific HLA antibodies in the patient is a contraindication for transplantation. The challenge is now to reach consensus on the parameters which predict the clinical relevance of donor specific HLA antibodies. Antibody screening assays should not only be used to prevent transplantation of patients with donor specific antibodies but also to facilitate transplantation of highly sensitized patients, both by defining acceptable HLA mismatches and non-detrimental donor specific HLA antibodies.

机译：非常敏感的HLA抗体筛选测定法的引入已经破坏了旧的教条，即患者体内供体特异性HLA抗体的预先存在是移植的禁忌症。现在的挑战是在预测供体特异性HLA抗体临床相关性的参数上达成共识。通过定义可接受的HLA错配和非有害的供体特异性HLA抗体，抗体筛选试验不仅应用于防止供体特异性抗体的患者移植，而且应促进高度敏感的患者的移植。

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《International journal of immunogenetics》 |2008年第5期|共3页
作者
Frans H. J. Claas;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Antibodies; HLA Antigens; transplantation; Aspects of disease screening; 抗体; HLA抗原;

机译：Antibodies;HLA Antigens;transplantation;Aspects of disease screening;抗体;HLA抗原;

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专利

1. HLA antibody testing: a tool to facilitate not to prevent organ transplantation [J] . Frans H. J. Claas International journal of immunogenetics . 2008,第4a5期

机译：HLA抗体测试：促进不预防器官移植的工具
2. EXTENDED AND HIGH-RESOLUTION HLA GENOTYPING OF KIDNEY TRANSPLANT PAIRS IS NECESSARY TO CORRECTLY ASSIGN DONOR-SPECIFIC HLA ANTIBODIES PRIOR TO SOLID-ORGAN TRANSPLANTATION [J] . Senev Aleksandar, Van Sandt Vicky, Naesens Maarten, Transplant international : . 2019,第S2期

机译：肾移植对的延长和高分辨率HLA基因分型是在固体器官移植之前正确分配给予特异性HLA抗体的必要条件
3. EXTENDED AND HIGH-RESOLUTION HLA TYPING OF TRANSPLANT PAIRS IS NECESSARY TO CORRECTLY ASSIGN DONOR SPECIFIC HLA ANTIBODIES PRIOR SOLID ORGAN TRANSPLANTATION [J] . Senev Aleksandar, Van Sandt Vicky, Naesens Maarten, HLA. . 2019,第5期

机译：延长和高分辨率HLA移植对的键入是必要的，以正确地分配现有的固体器官移植的供体特异性HLA抗体
4. TREATMENT OF REFRACTORY ANTIBODY MEDIATED REJECTION WITH BORTEZOMIB IN TWO TRANSPLANT RECIPIENTS: THE IMPACT ON DONOR-SPECIFIC ANTI-HLA ANTIBODIES [C] . John Lunz, Judy Howe, Lawrence Jelinek, Clinical Histocompatibility Workshop. . 2010

机译：治疗难治性抗体在两个移植受者中用硼替佐米介导的抑制剂：对供体特异性抗HLA抗体的影响
5. Antibody Approaches to Enable Hematopoietic Stem Cell and Organ Transplant [D] . George, Benson M. 2020

机译：抗体接近造血干细胞和器官移植的方法
6. HLA antibody testing: a tool to facilitate not to prevent organ transplantation [O] . Frans H J Claas -1

机译：HLA抗体测试：促进不预防器官移植的工具
7. HLA antibody testing: a tool to facilitate not to prevent organ transplantation [O] . Claas, Frans H J 2008

机译：HLA抗体测试：促进不预防器官移植的工具

HLA antibody testing: a tool to facilitate not to prevent organ transplantation

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