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首页> 外文期刊>International journal of immunogenetics >Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer.
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Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer.

机译：一组土耳其大肠癌患者CTLA-4和CD28基因多态性的调查。

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Colorectal cancer (CRC), also called colon cancer or bowel cancer, includes cancerous growths in the colon, rectum and appendix. The immune system is an important defence mechanism against cancer and is often dysfunctional in patients with malignancies. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and CD28 genes encode receptors that provide negative and positive signals, respectively. Polymorphisms in these genes can affect their functions. In this study, we aimed to investigate the association of cancer with the frequencies and roles of CTLA-4/+49A > G (exon 1) and -318C > T (promoter), and CD28/IVS3 + 17T > C (intron 3 position + 17). These polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 218 Turkish subjects (56 patients with CRC and 162 healthy controls). No statistically significant differences in the genotype distributions of CTLA-4/+49GG (1.8% vs. 6.8%, odds ratio (OR) = 0.250, P = 0.305) and CTLA-4/-318TT (0% vs. 0.6%, OR = 1.006, P = 1.000), and CD28/IVS3 + 17CC (8.9% vs. 3.7%, OR = 0.2411, P = 0.155) between patients with CRC and healthy controls, were observed. We also found that there were no significant differences in the frequencies of CTLA-4/+49G (18.8% vs. 20.1%, OR = 0.920, P = 0.891) and CTLA-4/-318T (7.1% vs. 4.3%, OR = 1.653, P = 0.314), and CD28/IVS3 + 17C alleles (25.9% vs. 19.1%, OR = 1.353, P = 0.139) between two study groups. Present results suggested that CTLA-4 and CD28 gene polymorphisms did not play an important role in Turkish patients with CRC.
机译：大肠癌（CRC），也称为结肠癌或肠癌，包括结肠，直肠和阑尾的癌性生长。免疫系统是抵抗癌症的重要防御机制，在恶性肿瘤患者中通常功能失调。细胞毒性T淋巴细胞相关抗原4（CTLA-4）和CD28基因编码分别提供负信号和正信号的受体。这些基因的多态性会影响其功能。在这项研究中，我们旨在研究癌症与CTLA-4 / + 49A> G（外显子1）和-318C> T（启动子）以及CD28 / IVS3 + 17T> C（内含子3）的频率和作用之间的关系。位置+ 17）。使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）对218例土耳其受试者（56名CRC患者和162名健康对照）进行基因分型。 CTLA-4 / + 49GG（1.8％vs.6.8％，优势比（OR）= 0.250，P = 0.305）和CTLA-4 / -318TT（0％vs. 0.6％， CRC患者与健康对照者之间观察到OR = 1.006，P = 1.000）和CD28 / IVS3 + 17CC（8.9％vs. 3.7％，OR = 0.2411，P = 0.155）。我们还发现，CTLA-4 / + 49G的频率（18.8％与20.1％，OR = 0.920，P = 0.891）和CTLA-4 / -318T的频率（7.1％与4.3％，两个研究组之间的OR = 1.653，P = 0.314）和CD28 / IVS3 + 17C等位基因（25.9％对19.1％，OR = 1.353，P = 0.139）。目前的结果表明，CTLA-4和CD28基因多态性在土耳其CRC患者中没有发挥重要作用。

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