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首页> 外文期刊>International journal of immunogenetics >Positive association of HLA-DRB1*15 with keloid disease in Caucasians.
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Positive association of HLA-DRB1*15 with keloid disease in Caucasians.

机译：HLA-DRB1 * 15与白种人的瘢痕loid疾病呈正相关。

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Keloid disease (KD) is a fibroproliferative dermal tumour of unknown aetiology. The increased familial clustering in KD, its increased prevalence in certain races and concordance in identical twins suggest a strong genetic predisposition to keloid formation. The most polymorphic genetic system in all vertebrates is the major histocompatibility complex (MHC) also known as the human leucocyte antigens (HLA) system. The MHC has been shown to be strongly associated with numerous conditions. Of particular interest is the association of DR2 with dermal fibrotic diseases such as sarcoidosis. To investigate the aetiology of KD, we compared the HLA-DRB1 phenotype frequencies of Caucasoid patients with keloid scars against those observed in a control population (n = 537). A total number of 67 keloid cases were evaluated in the study. HLA-DRB1 alleles were determined in all cases and controls using a commercially available semiautomated reverse hybridization polymerase chain reaction sequence-specific oligonucleotide probes typing system. HLA-DRB1*15 phenotype frequency was higher in KD-positive Caucasians (38.8%) when compared with controls (20.9%) (corrected P = 0.017). We conclude that in Caucasians of Northern European origin, HLA-DRB1*15 is associated with risk of developing KD following injury. We have demonstrated for the first time that a genetic association exists between HLA-DRB1*15 status and the risk of developing keloid scarring in Caucasians. Our data suggest the possible involvement of an immunogenic component to KD although the exact mechanisms involved in MHC-driven abnormal fibrosis will require further investigation.
机译：瘢痕loid病（KD）是一种病因不明的纤维增生性皮肤肿瘤。 KD家族聚集性增加，某些种族中患病率增加以及同卵双胞胎的一致性表明瘢痕loid形成的遗传易感性强。在所有脊椎动物中，最多态的遗传系统是主要的组织相容性复合体（MHC），也称为人白细胞抗原（HLA）系统。事实证明，MHC与多种疾病密切相关。特别令人感兴趣的是DR2与皮肤纤维化疾病如结节病的关系。为了调查KD的病因，我们比较了患有瘢痕s疤痕的高加索患者与对照组人群中观察到的HLA-DRB1表型频率（n = 537）。在该研究中评估了总共67例瘢痕loid病例。使用市售的半自动反向杂交聚合酶链反应序列特异性寡核苷酸探针分型系统在所有情况和对照中确定HLA-DRB1等位基因。与对照组（20.9％）相比，KD阳性高加索人的HLA-DRB1 * 15表型频率更高（38.8％）（校正后的P = 0.017）。我们得出结论，在北欧血统的高加索人中，HLA-DRB1 * 15与受伤后发生KD的风险有关。我们首次证明了HLA-DRB1 * 15状态与高加索人瘢痕loid形成风险之间存在遗传关联。我们的数据表明免疫原性成分可能与KD有关，尽管涉及MHC驱动的异常纤维化的确切机制仍需进一步研究。

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