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首页> 外文期刊>International journal of immunogenetics >Distribution of killer cell immunoglobulin-like receptor genes in Poles.
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Distribution of killer cell immunoglobulin-like receptor genes in Poles.

机译:波兰人杀伤细胞免疫球蛋白样受体基因的分布。

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摘要

Killer cell immunoglobulin-like receptors (KIRs) present on natural killer cells and minor subpopulations of T cells recognize class I human leucocyte antigen (HLA) molecules on the surface of target cells. Humans differ by the presence or absence of some KIR genes on their chromosomes. As KIRs are important for the outcome of tissue transplantation (particularly for haematopoietic stem cell transplantation) and possibly for pregnancy and autoimmune diseases, knowledge of the KIR gene distribution in a given human population is of practical value. Therefore, we tested 363 healthy individuals from Western Poland for the presence or absence of KIR genes. Results are compared with those published for other human populations. KIR gene frequencies in Poles are close to these in other Caucasoids but different from those in Asian and African populations, and particularly distant from those in Australian Aborigines.
机译:存在于自然杀伤细胞上的杀伤细胞免疫球蛋白样受体(KIR)和少量T细胞亚群可识别靶细胞表面的I类人类白细胞抗原(HLA)分子。人类因染色体上是否存在某些KIR基因而有所不同。由于KIR对于组织移植(尤其是造血干细胞移植)的结果以及可能对妊娠和自身免疫性疾病很重要,因此了解KIR基因在特定人群中的分布具有实用价值。因此,我们测试了来自波兰西部的363位健康个体的KIR基因存在与否。将结果与其他人群的结果进行比较。波兰人的KIR基因频率与其他高加索人的频率接近,但与亚洲和非洲人口的KIR基因频率不同,特别是与澳大利亚原住民的基因频率相距甚远。

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