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首页> 外文期刊>International journal of immunogenetics >Immunogenetics in haematology and stem cell transplantation
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Immunogenetics in haematology and stem cell transplantation

机译：血液学和干细胞移植的免疫遗传学

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European Commission supported medical projects facilitate the translation of basic research into clinical practice. This is especially seen in rapidly developing specialties including the transplantation of haematopoietic stem cells. In this field the projects were aimed at increasing the number of patients that could benefit from haematopoietic stem cell transplantation (HSCT) and implementing new technologies that could increase the rate of patients enjoying long-term disease-free survival post-transplantation. The decreasing size of families, especially in Europe, has increased the demand for transplantation of haematopoietic stem cells obtained from unrelated donors. Due to campaigns for unrelated donor registries and the positive response of society, there has been an increase in the pool of unrelated donors to almost 12 million volunteers worldwide. This increase is very fortunately associated with tremendous progress in immunogenetics after implementation of HLA DNA typing, which makes it possible to match donors and recipients on the basis of single nucleotides precisely describing the specificities in five loci of human leucocyte antigen (HLA). Studies that led to this successful approach were in Europe supported by the European Union.
机译：欧盟委员会支持的医学项目有助于将基础研究转化为临床实践。这在快速发展的专业（包括造血干细胞的移植）中尤为明显。在该领域中，这些项目旨在增加受益于造血干细胞移植（HSCT）的患者数量，并实施新技术以提高患者在移植后享有长期无病生存的比率。家庭规模的减少，尤其是在欧洲，增加了对从无关亲戚那里获得的造血干细胞移植的需求。由于开展了不相关捐助者登记的运动以及社会的积极回应，全世界不相关捐助者的数量已增加到近1200万志愿者。幸运的是，这种增加与实施HLA DNA分型后免疫遗传学的巨大进步有关，这使得可以基于精确描述人类白细胞抗原（HLA）五个基因座特异性的单核苷酸匹配供体和受体。导致这种成功方法的研究在欧洲得到了欧盟的支持。

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