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首页> 外文期刊>International journal of immunogenetics >Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations.
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Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations.

机译：与人类HLA数据进行组织相容性，临床移植，流行病学和人口遗传学研究的策略：HLA-NET方法学建议。

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HLA-NET (a European COST Action) aims at networking researchers working in bone marrow transplantation, epidemiology and population genetics to improve the molecular characterization of the HLA genetic diversity of human populations, with an expected strong impact on both public health and fundamental research. Such improvements involve finding consensual strategies to characterize human populations and samples and report HLA molecular typings and ambiguities; proposing user-friendly access to databases and computer tools and defining minimal requirements related to ethical aspects. The overall outcome is the provision of population genetic characterizations and comparisons in a standard way by all interested laboratories. This article reports the recommendations of four working groups (WG1-4) of the HLA-NET network at the mid-term of its activities. WG1 (Population definitions and sampling strategies for population genetics' analyses) recommends avoiding outdated racial classifications and population names (e.g. 'Caucasian') and using instead geographic and/or cultural (e.g. linguistic) criteria to describe human populations (e.g. 'pan-European'). A standard 'HLA-NET POPULATION DATA QUESTIONNAIRE' has been finalized and is available for the whole HLA community. WG2 (HLA typing standards for population genetics analyses) recommends retaining maximal information when reporting HLA typing results. Rather than using the National Marrow Donor Program coding system, all ambiguities should be provided by listing all allele pairs required to explain each genotype, according to the formats proposed in 'HLA-NET GUIDELINES FOR REPORTING HLA TYPINGS'.
机译：HLA-NET（一项欧洲COST行动）旨在使从事骨髓移植，流行病学和人群遗传学研究的研究人员联网，以改善人类HLA遗传多样性的分子表征，并有望对公共卫生和基础研究产生重大影响。这些改进包括寻找共识性的策略来表征人群和样本，并报告HLA分子的类型和歧义。提出对数据库和计算机工具的用户友好访问，并定义与道德方面有关的最低要求。总体结果是所有感兴趣的实验室都以标准方式提供了种群遗传特征和比较。本文报告了HLA-NET网络的四个工作组在其活动中期的建议。第一工作组（人口遗传学分析的人口定义和抽样策略）建议避免过时的种族分类和人口名称（例如“高加索人”），而应使用地理和/或文化（例如语言）标准来描述人口（例如“泛欧洲人”） '）。一个标准的“ HLA-网络人口数据问题问卷”已经定稿，可用于整个HLA社区。 WG2（用于群体遗传学分析的HLA分型标准）建议在报告HLA分型结果时保留最大信息。不应使用“国家骨髓捐献者计划”编码系统，而应根据“ HLA TYPIN报道指南”中提出的格式，列出解释每种基因型所需的所有等位基因对，以提供所有歧义。

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