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首页> 外文期刊>International journal of immunogenetics >Vascular endothelial growth factor +405 G/C,-460 T/C and -2578 A/C polymorphisms are not associated with insulin resistance in polycystic ovary syndrome.
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Vascular endothelial growth factor +405 G/C,-460 T/C and -2578 A/C polymorphisms are not associated with insulin resistance in polycystic ovary syndrome.

机译：血管内皮生长因子+405 G / C，-460 T / C和-2578 A / C多态性与多囊卵巢综合征的胰岛素抵抗无关。

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摘要

Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 A/C polymorphisms of VEGF gene with fasting glucose, fasting insulin and the indices of IR [glucose/insulin ratio (GIR), homoeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI)] in 137 patients with PCOS. None of the studied polymorphisms were found to affect IR indices significantly. However, there was a trend towards higher HOMA in +405 G and -460 T allele carriers in comparison with homozygotes +405 CC and -460 CC, respectively. With regard to -2578 A/C polymorphism, although not significant, in -2578 C carriers HOMA was lower, and GIR was higher in comparison with -2578 AA genotype. Alteration of QUICKI between genotypes was minimal and varied from 4% to 7%. Because of the relatively small sample size, more studies with greater number of cases are necessary to confirm our observations before any statement can be made about the relationship between VEGF gene polymorphism and IR parameters in PCOS.
机译：胰岛素抵抗（IR）和胰腺β细胞功能异常是多囊卵巢综合征（PCOS）的常见合并症。已知血管内皮生长因子（VEGF）在PCOS的发病机理中起重要作用。这项研究首先研究了VEGF基因的+405 G / C，-460 T / C和-2578 A / C多态性与空腹血糖，空腹胰岛素和IR指数[葡萄糖/胰岛素比（GIR），稳态模型评估（HOMA）和定量胰岛素敏感性检查指数（QUICKI）]在137例PCOS患者中。没有一个研究的多态性被发现会显着影响红外指数。然而，与纯合子+405 CC和-460 CC相比，+ 405 G和-460 T等位基因携带者有更高的HOMA趋势。关于-2578 A / C多态性，尽管不显着，但与-2578 AA基因型相比，在-2578 C载体中HOMA更低，而GIR更高。基因型之间QUICKI的变化极小，从4％到7％不等。由于样本量相对较小，因此在对PCOS中VEGF基因多态性与IR参数之间的关系做出任何陈述之前，需要进行更多的研究以证实我们的观察结果。

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