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首页> 外文期刊>International journal of immunopharmacology >Effects of hyaluronan on models of immediate and delayed hypersensitivity in the rat.
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Effects of hyaluronan on models of immediate and delayed hypersensitivity in the rat.

机译：透明质酸对大鼠立即和迟发型超敏反应模型的影响。

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摘要

Others have previously shown that superoxide dismutase conjugated with hyaluronan (HA) retains enzymic activity but is non-immunogenic. Whether HA could be widely used to prevent sensitisation to protein/polypeptide therapeutics is not known. In this study we investigated the effects of HA on bovine serum albumin (BSA) and methylated BSA pleural reactions in sensitised rats (active Arthus and delayed hypersensitivity reactions respectively) and on a reverse passive Arthus reaction in which rats received an intravenous injection of rabbit immunoglobulin and intrapleural challenge with goat anti rabbit immunoglobulin. HA suppressed the active Arthus and delayed hypersensitivity models when administered at the time of sensitisation but only the delayed hypersensitivity model at the time of intrapleural challenge. HA did not modulate the reverse passive Arthus reaction. The results show no evidence that simple mixing of HA with antigens masks antigenic determinants. However, HA appeared to have suppressive effects on both antibody and cell-mediated immune reactions. Therefore it may not be necessary to conjugate protein/polypeptide therapeutics to HA in order to prevent immune sensitisation.
机译：先前的其他研究表明，与透明质酸（HA）偶联的超氧化物歧化酶保留了酶活性，但没有免疫原性。 HA是否可以广泛用于防止对蛋白质/多肽治疗剂致敏尚不清楚。在这项研究中，我们研究了HA对致敏大鼠的牛血清白蛋白（BSA）和甲基化BSA胸膜反应（分别为主动Arthus和迟发性超敏反应）以及反向被动Arthus反应的影响，在该反应中，大鼠接受了静脉注射兔免疫球蛋白和山羊抗兔免疫球蛋白的胸膜内攻击。 HA在致敏时给予抑制活动性Arthus和迟发性超敏反应模型，而在胸膜内刺激时仅抑制迟发性超敏反应模型。 HA没有调节反向被动Arthus反应。结果表明没有证据表明HA与抗原的简单混合掩盖了抗原决定簇。然而，HA似乎对抗体和细胞介导的免疫反应均具有抑制作用。因此，可能不需要将蛋白质/多肽治疗剂与HA偶联以防止免疫致敏。

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