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首页> 外文期刊>International journal of immunopharmacology >The effects of allopurinol on immune function in normal BALB/c and SCID mice.
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The effects of allopurinol on immune function in normal BALB/c and SCID mice.

机译：别嘌醇对正常BALB / c和SCID小鼠免疫功能的影响。

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摘要

To clarify the relationship between purine metabolism and immunity, the in vivo immunosuppressive effects of allopurinol (AL), a xanthinoxidase (XO) inhibitor, were studied using normal BALB/c and severe combined immunodeficient (SCID) mice. Following AL administration for 14 weeks (long term), a decreased immune response to ovalbumin (OVA) in the peripheral blood was observed in normal mice, which might not be only due to direct B cell suppression but also due to suppression of helper T cell function. In the SCID mice, there was a markedly late and reduced recovery of surface immunoglobulin (sIg) positive cells, which are markers for mature B lymphocytes, in the peripheral blood after AL administration. The total immunoglobulin G (IgG) titers in the AL treated group were significantly lower than in the control group 6 weeks after stem cell transfer, but increased until there was no difference in the titers between the two groups at week 14. CD4 positive helper T cells and CD8 positive T cells were slow to recover, though these gradually recovered to reach normal levels in the mature stage. These data suggest that the administration of AL may modulate B cell and T cell responses in OVA-immunized antibody formation. Furthermore, this study showed that AL could influence immune functions during the pre-natal and developmental periods and that its effects might differ according to the stages of maturity of the immune cells.
机译：为了阐明嘌呤代谢与免疫之间的关系，使用正常的BALB / c和严重的联合免疫缺陷（SCID）小鼠研究了黄嘌呤醇（AL）（一种黄嘌呤氧化酶（XO）抑制剂）的体内免疫抑制作用。 AL给药14周（长期）后，在正常小鼠中观察到对外周血卵白蛋白（OVA）的免疫反应降低，这可能不仅是由于直接抑制B细胞，而且还由于抑制了辅助性T细胞功能。在SCID小鼠中，AL给药后外周血中表面免疫球蛋白（sIg）阳性细胞（成熟B淋巴细胞的标志物）的恢复明显较晚且降低了。干细胞转移后6周，AL治疗组的总免疫球蛋白G（IgG）滴度显着低于对照组，但直到第14周两组之间的滴度无差异为止。细胞和CD8阳性T细胞的恢复较慢，尽管它们在成熟阶段逐渐恢复至正常水平。这些数据表明，AL的施用可以在OVA免疫的抗体形成中调节B细胞和T细胞应答。此外，这项研究表明，AL可能会影响产前和发育期的免疫功能，并且其作用可能会因免疫细胞的成熟阶段而异。

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