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首页> 外文期刊>International journal of immunogenetics >Inhibitory and activatory KIR gene frequencies in the Polish population.
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Inhibitory and activatory KIR gene frequencies in the Polish population.

机译:波兰人口中抑制性和活化性KIR基因频率。

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摘要

Killer cell immunoglobulin-like receptors (KIRs) present on natural killer cells and minor subpopulations of T cells recognize class I human leukocyte antigen (HLA) molecules on the surface of target cells. Human individuals differ by the presence or absence of some KIR genes on their chromosomes (haplotypic polymorphism). As KIRs (especially two-immunoglobulin-domain-like containing, or KIR2D, molecules) are important for the outcome of tissue (particularly for haematopoietic stem cell) transplantation and possibly for pregnancy, the knowledge of KIR gene distribution in a given human population is of practical value. Therefore, we tested 175 healthy individuals from Poland for the presence or absence of these KIR genes which show haplotypic polymorphism and are expressed. Results were compared with those published for other human populations, showing close relations with other Caucasoids.
机译:存在于自然杀伤细胞上的杀伤细胞免疫球蛋白样受体(KIR)和少量T细胞亚群可识别靶细胞表面的I类人类白细胞抗原(HLA)分子。人类个体的染色体上是否存在某些KIR基因(单倍型多态性)有所不同。由于KIR(特别是含有两个免疫球蛋白结构域的分子或KIR2D分子)对于组织(尤其是造血干细胞)移植的结果以及可能对妊娠至关重要,因此在特定人群中了解KIR基因分布的知识是具有实用价值。因此,我们测试了来自波兰的175名健康个体是否存在这些KIR基因,这些基因显示出单倍型多态性并被表达。将结果与针对其他人群发表的结果进行了比较,显示与其他高加索人有密切关系。

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