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首页> 外文期刊>International journal of immunogenetics >Lack of association between ADAM33 gene and asthma in a Chinese population.
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Lack of association between ADAM33 gene and asthma in a Chinese population.

机译：在中国人群中，ADAM33基因与哮喘之间缺乏关联。

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Asthma is a complex polygenic disease with gene-environment interactions being important. It has been previously suggested that ADAM33, which is a member of a gene family that encodes membrane-anchored proteins with a disintegrin and a metalloprotease domain, is primarily expressed in lung fibroblasts and bronchial smooth muscle cells and has been associated with airway remodelling and bronchial hyperresponsiveness. A significant association has previously been demonstrated between single nucleotide polymorphisms (SNPs) and haplotypes of the ADAM33 and asthma in ethnically diverse populations. To assess whether SNPs or haplotypes of ADAM33 are related to asthma in a Chinese Han population, we genotyped three SNPs of ADAM33 (7575G/A in intron 6, 11188A/T in intron 19, and 12433T/C in exon 20) in a case-control study involving 296 patients with asthma and 270 healthy controls. No significant association was detected between these three SNPs and asthma susceptibility in the Chinese population.
机译：哮喘是一种复杂的多基因疾病，其基因与环境之间的相互作用非常重要。以前曾有人提出，ADAM33是编码具有整合蛋白和金属蛋白酶结构域的膜锚定蛋白的基因家族的成员，主要在肺成纤维细胞和支气管平滑肌细胞中表达，并与气道重塑和支气管相关高反应性。以前已经证明了单核苷酸多态性（SNP）与ADAM33的单倍型和哮喘在不同种族的人群之间存在显着关联。为了评估中国汉族人群中ADAM33的SNP或单倍型是否与哮喘相关，我们对一个案例中的三个ADAM33的SNP进行了基因分型（内含子6为7755G / A，内含子19为11188A / T，外显子20为12433T / C）。对照研究涉及296例哮喘患者和270例健康对照。在中国人群中，这三个SNP与哮喘易感性之间未发现显着关联。

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