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首页> 外文期刊>International journal of immunopharmacology >Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components.
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Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components.

机译：防止芦荟凝胶成分对紫外线引起的接触性超敏反应的抑制。

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摘要

We have recently reported that Aloe vera gel contains small molecular weight immunomodulators, G1C2F1, that restore ultraviolet B (UVB)-suppressed accessory cell function of epidermal Langerhans cells (LC) in vitro. In the present study we evaluated the UVB-protective activity of G1C2F1 in vivo. Exposure of the shaved abdominal skin of mice to 2.4 KJ/m2 of UVB radiation resulted in suppression of contact sensitization through the skin to 41.1%, compared to normal unirradiated skin. Topical application of G1C2F1 immediately after irradiation reduced this suppression significantly. The percentage recovery of UVB-suppressed contact hypersensitivity (CHS) response was 52.3, 77.3, and 86.6% when the irradiated skin was treated once with 0.1, 0.5, and 2.5 mg/ml of G1C2F1-containing cream, respectively. G1C2F1 did not show nonspecific stimulatory activity on CHS response. The present study, together with the previous observation, show that Aloe vera gel contains small molecular weight immunomodulators that prevent UVB-induced immune suppression in the skin by restoration of UVB-induced damages on epidermal LC.
机译：我们最近报道，芦荟凝胶包含小分子免疫调节剂G1C2F1，可在体外恢复紫外线B（UVB）抑制的表皮朗格汉斯细胞（LC）的辅助细胞功能。在本研究中，我们评估了G1C2F1在体内的UVB保护活性。与正常的未辐照皮肤相比，将小鼠剃毛的腹部皮肤暴露于2.4 KJ / m2的UVB辐射可导致皮肤接触致敏性降低至41.1％。照射后立即局部应用G1C2F1可以显着降低这种抑制作用。当分别用0.1、0.5和2.5 mg / ml的含G1C2F1的乳霜处理照射过的皮肤后，UVB抑制的接触超敏反应（CHS）响应的恢复百分比分别为52.3、77.3和86.6％。 G1C2F1没有显示对CHS反应的非特异性刺激活性。本研究与先前的观察结果表明，芦荟凝胶含有小分子量免疫调节剂，可通过恢复表皮LC上UVB诱导的损伤来防止UVB诱导的皮肤免疫抑制。

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