Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5.

Allen M; Pratscher B; Krepler C; Frei K; Schofer C; Pehamberger H; Muller M; Lucas T

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Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5.

机译：通过缺失外显子3和5替代黑素细胞中IL-24的剪接

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Two novel interleukin-24 (IL-24) splice variants were identified in normal human melanocytes by sequencing cloned polymerase chain reaction (PCR) products that are not expressed in metastatic melanoma. These gene products have been generated by differential skipping of exons 3 (IL-24 delE3) and 5 (IL-24 delE5). IL-24 delE3 has limited sequence identity to the IL-24-interacting protein mda-7s, and IL-24 delE5 is homologous to IL-24.

机译：通过对未在转移性黑素瘤中表达的克隆的聚合酶链反应（PCR）产物进行测序，在正常人黑素细胞中鉴定出两个新的白介素-24（IL-24）剪接变体。这些基因产物是通过外显子3（IL-24 delE3）和5（IL-24 delE5）外显子跳过而产生的。 IL-24 delE3与与IL-24相互作用的蛋白质mda-7s具有有限的序列同一性，而IL-24 delE5与IL-24同源。

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来源
《International journal of immunogenetics》 |2005年第6期|共4页
作者
Allen M; Pratscher B; Krepler C; Frei K; Schofer C; Pehamberger H; Muller M; Lucas T;
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正文语种 eng
中图分类基础医学;
关键词
Alternative Splicing; Exons; Interleukins; Melanocytes; RNA; Messenger; 交替剪接; 外显子; 白细胞介素类; 黑素细胞; RNA; 信使;

机译：Alternative Splicing;Exons;Interleukins;Melanocytes;RNA;Messenger;交替剪接;外显子;白细胞介素类;黑素细胞;RNA;信使;

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专利

1. Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5. [J] . Allen M, Pratscher B, Krepler C, International journal of immunogenetics . 2005,第6期

机译：通过缺失外显子3和5替代黑素细胞中IL-24的剪接
2. An Alu-mediated 7.1 kb deletion of BRCA1 exons 8 and 9 in breast and ovarian cancer families that results in alternative splicing of exon 10. [J] . Rohlfs EM, Puget N, Graham ML, Genes, Chromosomes and Cancer . 2000,第3期

机译：在乳腺癌和卵巢癌家族中，Alu介导的BRCA1外显子8和9的7.1 kb缺失导致了外显子10的可变剪接。
3. A new HLA-B44 allele (B*44020102S) with a splicing mutation leading to a complete deletion of exon 5. [J] . Dubois V, Tiercy JM, Labonne MP, Tissue antigens. . 2004,第2期

机译：新的HLA-B44等位基因（B * 44020102S）具有剪接突变，导致第5外显子完全缺失。
4. A classification of alternatively spliced cassette exons using AdaBoost-based algorithm [C] . Li Liang, Peng Qinke, Shakoor Adnan, IEEE International Conference on Information and Automation . 2014

机译：使用基于AdaBoost的算法对选择性剪接的盒式外显子进行分类
5. Exosomal proteome changes induced by human tau expression are modulated by the presence of the microtubule-binding domain and alternatively spliced exons 2-3 in SH-SY5Y neuroblastoma cells [D] . Aladwan, Mohammad Mahmoud. 2017

机译：SH-SY5Y神经母细胞瘤细胞中微管结合结构域的存在和其他剪接的外显子2-3的存在可以调节人tau表达诱导的外泌体蛋白质组变化
6. CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion [O] . Haiwei Mou, Jordan L. Smith, Lingtao Peng, 2017

机译：CRISPR / Cas9介导的基因组编辑通过选择性剪接或外显子缺失诱导外显子跳跃
7. An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor [O] . Smith P. J., Spurrell E. L., Coakley J., 2002

机译：人类IGF-I pre-mRNA中的外显子剪接增强子通过丝氨酸-精氨酸蛋白剪接因子-2 /其他剪接因子介导对备选外显子5的识别

Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5.

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