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IL-12B and IL-10 gene polymorphisms in the development of Hashimoto's thyroiditis

机译：IL-12B和IL-10基因多态性在桥本甲状腺炎发展中的作用

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Functional genetic polymorphisms that altered gene expression of cytokines are candidate genetic factors that could modulate the development and progression of Hashimoto's thyroiditis (HT). IL-12B gene encoded the IL-12p40 subunit, which is included in the pro-inflammatory heterodimeric cytokines IL-12p70 and IL-23. IL-10 is an important Treg cytokine suppressing inflammatory cytokine production and autoimmunity. This study was designed to compare - 1082A/GIL-10 and +1188A/C30UTRIL-12B genotype distribution in 130 patients with HT to a group of 157 healthy controls in attempts to determine an association with HT development. Genotyping for the 30UTRA/C IL-12B polymorphism was performed using RFLP-PCR and genotyping for - 1082A/G IL-10 by ARMS-PCR assay. Patients with HT were divided into euthyroid and hypothyroid stages. There were no significant differences in the genotype and allele frequencies of the IL-12B polymorphism between patients with HT and controls. We observed higher euthyroid HT risk for individuals with CC genotype, unlike to develop hypothyroidism with OR = 1.68. Regarding the polymorphism rs1800896, it was shown the significantly higher frequency of homozygous genotype GG in cases vs controls (OR = 2.19; P = 0.024). Moreover, the combination of genotype AA of 30UTRIL-12B with GG of -1082IL-10 was associated with a threefold increasing risk (OR = 3.188; P = 0.022) of developing HT compared to individuals with the presence of 30UTR allele C (AC+ CC) simultaneously with AA genotype of -1082IL-10. Our data raise the possibility that the combined effect of polymorphisms from proinflammatory and anti-inflammatory cytokines may be more decisive to HT development.
机译：改变细胞因子基因表达的功能性遗传多态性是候选遗传因子，可调节桥本甲状腺炎（HT）的发展和进程。 IL-12B基因编码IL-12p40亚基，包括在促炎性异二聚体细胞因子IL-12p70和IL-23中。 IL-10是一种重要的Treg细胞因子，可抑制炎性细胞因子的产生和自身免疫。本研究旨在比较130例HT患者的1082A / GIL-10和+ 1188A / C30UTRIL-12B基因型分布与157名健康对照者的基因分布，以试图确定与HT发生的相关性。使用RFLP-PCR对30UTRA / C IL-12B多态性进行基因分型，并通过ARMS-PCR分析对-1082A / G IL-10进行基因分型。 HT患者分为甲状腺功能正常和甲状腺功能减退。 HT患者与对照组之间IL-12B多态性的基因型和等位基因频率无显着差异。我们观察到CC基因型个体有较高的甲状腺功能正常HT风险，而OR = 1.68会导致甲状腺功能减退。关于多态性rs1800896，显示纯合子基因型GG的频率明显高于对照组（OR = 2.19; P = 0.024）。此外，与存在30UTR等位基因C（AC + CC）的个体相比，基因型30UTRIL-12B的AA与GG的-1082IL-10的组合与患HT的风险增加了三倍（OR = 3.188; P = 0.022） ）与-1082IL-10的AA基因型同时出现。我们的数据提出了以下可能性：促炎和抗炎细胞因子的多态性联合作用可能对HT的发展起决定性作用。

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