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首页> 外文期刊>International journal of immunogenetics >Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy
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Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy

机译：妊娠晚期杀伤细胞免疫球蛋白样受体和巨细胞病毒激活

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Human cytomegalovirus (CMV) represents an important public health concern as it is associated with severe morbidity and mortality in transplant recipients, HIV-infected individuals and pregnant women given the risk of congenital infection. Congenital CMV is a leading cause of neurological sequelae, developmental delay and birth defects worldwide. Cytomegalovirus can be transmitted to the foetus following maternal infection or reactivation. NK cells expressing killer-cell immunoglobulin-like receptors (KIR) are part of the innate immune system and the first line of defence against viral incursions. Previous reports have shown that KIR genes are associated with CMV infections in the post-transplant setting. In this study, we set out to determine whether a protective effect of KIR genes over CMV infection is seen in Mexican pregnant women. Cytomegalovirus infection was assessed through nucleic acid testing in 200 pregnant women and 600 healthy blood donors comprising the Mexican mestizo reference population. Killer-cell immunoglobulin-like receptors and HLA-C genotypes were obtained from 200 pregnant women and 300 reference samples using a comprehensive PCR-SSP approach. We observed statistically lower carrier frequencies of cB03|tA01 gene-content haplotype, of cB03 haplotype motif, of the KIR2DL5+2DS3/2DS5 gene pair and of KIR2DL5 amongst CMV-positive pregnant women in comparison with those CMV negative. None of these were associated with CMV status in the reference population. Logistic regression analysis revealed that the most important factor determining CMV status during third-trimester pregnancies was the KIR2DL5+2DS3/2DS5 gene pair (OR 0.376 (95%CI 0.174, 0.811, P=0.013). Our results indicate that CMV-protective KIR gene associations described in Caucasoid populations are also present in the genetically distinct Mexican mestizo population. Our results suggest that certain KIR gene combinations provide protection against CMV infections occurring during late-term pregnancies, a finding of utmost epidemiological importance given its implication with congenital CMV infections.
机译：人类巨细胞病毒（CMV）代表着重要的公共卫生问题，因为它与移植受者，HIV感染者和有先天性感染风险的孕妇的严重发病率和死亡率相关。先天性巨细胞病毒是全球神经系统后遗症，发育迟缓和出生缺陷的主要原因。巨细胞病毒可在孕产妇感染或激活后传播给胎儿。表达杀伤细胞免疫球蛋白样受体（KIR）的NK细胞是先天免疫系统的组成部分，也是抵御病毒入侵的第一道防线。先前的报道表明，KIR基因在移植后的环境中与CMV感染有关。在这项研究中，我们着手确定在墨西哥孕妇中是否发现了KIR基因对CMV感染的保护作用。通过对包括墨西哥混血儿参考人群在内的200名孕妇和600名健康献血者进行了核酸检测，评估了巨细胞病毒感染。使用全面的PCR-SSP方法从200名孕妇和300个参考样本中获得了杀伤细胞免疫球蛋白样受体和HLA-C基因型。与CMV阴性的孕妇相比，我们在CMV阳性孕妇中观察到cB03 | tA01基因含量单倍型，cB03单倍型基序，KIR2DL5 + 2DS3 / 2DS5基因对和KIR2DL5的载波频率较低。这些均与参考人群中的CMV状态无关。 Logistic回归分析表明，决定妊娠晚期CMV状态的最重要因素是KIR2DL5 + 2DS3 / 2DS5基因对（OR 0.376（95％CI 0.174，0.811，P = 0.013）），我们的结果表明CMV保护性KIR高加索人群中描述的基因关联也存在于遗传上截然不同的墨西哥混血种群中，我们的结果表明某些KIR基因组合可提供针对晚期妊娠期间发生的CMV感染的保护，鉴于其与先天性CMV感染有关，这一发现在流行病学上具有重要意义。

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