• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >Association between interleukin-21 gene polymorphisms (rs12508721) and HBV-related hepatocellular carcinoma
【24h】

Association between interleukin-21 gene polymorphisms (rs12508721) and HBV-related hepatocellular carcinoma

机译：白细胞介素21基因多态性（rs12508721）与HBV相关性肝细胞癌的相关性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Interleukin-21 (IL-21), as a multifunctional cytokine, plays an important role in many diseases, such as cancer, inflammatory and autoimmune diseases. We aimed to investigate the relationship between polymorphisms of IL-21 gene and susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in a Chinese population. Studied subjects were divided into three groups: 100 patients with HBV-related HCC, 115 patients with chronic HBV infection and 127 healthy controls. Genomic DNA was isolated from peripheral blood, and the polymerase chain reaction-ligase detection reaction (PCR-LDR) method was used to genotype the SNPs (rs2221903, rs907715 and rs12508721) within IL-21 gene. Our results showed that IL-21 polymorphisms were associated with the risk of HCC and chronic HBV infection when compared with healthy controls. The rs2221903A/G AG genotype was associated with a higher risk of chronic HBV infection when compared with healthy controls [AG versus AA + GG, P = 0.036, OR = 1.898, 95% CI = 1.038-3.471]. The rs12508721C/T TT genotype was related with a lower risk of chronic HBV infection and HBV-related HCC than in healthy controls [TT versus CT + CC, P = 0.026, OR = 0.451, 95% CI = 0.221-0.920; P = 0.049, OR = 0.482, 95% CI = 0.231-1.005]. No significant difference in the genotype and allele distrubutions of rs907715G/A SNP was observed in the HBV-related HCC group, chronic HBV-infected group and the healthy control group when compared to each other. Our findings suggest that the rs12508721T/C and rs2221903A/G polymorphisms of IL-21 gene are associated with the susceptibility of HBV-related HCC and chronic HBV infection. The genetic variant may in fact cause protection against the HBV-related HCC. However, the function in these SNPs of IL-21 gene needs to clarify the mechanisms involved in the pathogenesis of HBV-related HCC further.
机译：白介素21（IL-21），作为一种多功能的细胞因子，在许多疾病中发挥重要作用，例如癌症，炎性疾病和自身免疫性疾病。我们旨在调查中国人群中IL-21基因多态性与乙型肝炎病毒（HBV）相关的肝细胞癌（HCC）的易感性之间的关系。研究对象分为三组：100例HBV相关性HCC患者，115例慢性HBV感染患者和127名健康对照者。从外周血中分离基因组DNA，并用聚合酶链反应-连接酶检测反应（PCR-LDR）方法对IL-21基因内的SNP（rs2221903，rs907715和rs12508721）进行基因分型。我们的结果表明，与健康对照组相比，IL-21多态性与HCC和慢性HBV感染的风险有关。与健康对照组相比，rs2221903A / G AG基因型与较高的慢性HBV感染风险相关[AG与AA + GG，P = 0.036，OR = 1.898，95％CI = 1.038-3.471]。 rs12508721C / T TT基因型与健康对照组相比，具有较低的慢性HBV感染和HBV相关HCC风险[TT vs CT + CC，P = 0.026，OR = 0.451，95％CI = 0.221-0.920; P = 0.049，OR = 0.482，95％CI = 0.231-1.005]。与之相比，在HBV相关HCC组，慢性HBV感染组和健康对照组中，rs907715G / A SNP的基因型和等位基因分布没有显着差异。我们的发现表明，IL-21基因的rs12508721T / C和rs2221903A / G多态性与HBV相关HCC和慢性HBV感染的易感性有关。实际上，遗传变异可能会导致针对HBV相关HCC的保护。然而，IL-21基因的这些SNP中的功能需要进一步阐明与HBV相关的HCC的发病机理有关的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号