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首页> 外文期刊>Biochemical Genetics >Association of B3GNT5 polymorphisms with susceptibility to ETEC F4ab/ac in the white duroc × erhualian intercross and 15 outbred pig breeds
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Association of B3GNT5 polymorphisms with susceptibility to ETEC F4ab/ac in the white duroc × erhualian intercross and 15 outbred pig breeds

机译：B3GNT5基因多态性与白色duroc×二化lian杂交和15个近交猪品种对ETEC F4ab / ac的敏感性相关

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摘要

The B3GNT5 gene is a candidate for the F4ab/ac receptor conferring susceptibility to enterotoxigenic Escherichia coli (ETEC) F4ab/ac in pigs. In this study, we screened mutations in the complete coding region of the porcine B3GNT5 gene and identified four SNPs in the 3a?2 untranslated regions. We genotyped the four SNPs across a large-scale White Duroc × Chinese Erhualian F 2 resource population (total F 2 = 755) and 292 purebred piglets representing 15 Chinese and Western breeds. We found that the g.1476G→A locus and haplotypes [A;T;G;T] and [A;G;G;T] had significant association with susceptibility to ETEC F4ac in the resource population. None of the B3GNT5 polymorphisms and haplotypes was associated with susceptibility to ETEC F4ab/ac in outbred piglets. This result, together with other reports, supports the conclusion that B3GNT5 is not the responsible gene encoding the ETEC F4ab/ac receptors.
机译：B3GNT5基因是F4ab / ac受体的候选基因，可赋予猪肠毒素原性大肠杆菌（ETEC）F4ab / ac敏感性。在这项研究中，我们筛选了猪B3GNT5基因完整编码区的突变，并在3a？2非翻译区中鉴定出四个SNP。我们对大白杜洛克×中国二化lian F 2资源种群（总F 2 = 755）和292个代表15个中西方品种的纯种仔猪的4个SNP进行了基因分型。我们发现g.1476G→A位点和单倍型[A; T; G; T]和[A; G; G; T]与资源种群中对ETEC F4ac的敏感性密切相关。 B3GNT5多态性和单倍型均与近亲仔猪对ETEC F4ab / ac的易感性无关。该结果与其他报道一起支持以下结论：B3GNT5不是编码ETEC F4ab / ac受体的负责任基因。

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