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首页> 外文期刊>British journal of ophthalmology >Orbital development in survivors of retinoblastoma treated by enucleation with hydroxyapatite implant.
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Orbital development in survivors of retinoblastoma treated by enucleation with hydroxyapatite implant.

机译：用羟基磷灰石植入物去核治疗视网膜母细胞瘤幸存者的眼眶发育。

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AIMS: To determine the impact of enucleation with hydroxyapatite implant on bony orbital development in survivors of retinoblastoma (RB) by measuring orbital volume based on CT imaging. METHODS: The authors used CT images obtained at a median age of 6 years to measure orbital volume of RB and contralateral orbits in 18 patients who underwent enucleation with hydroxyapatite implant for RB. Comparison of the orbital volume of RB and contralateral orbits was done using the Wilcoxon rank sum test. RESULTS: The mean age at diagnosis and operation was 29+/-23 months, and the mean follow-up was 49+/-31 months. The mean volume difference between RB and contralateral orbits was 0.93+/-1.13 cm(3). RB orbits with hydroxyapatite implant were statistically significantly smaller than contralateral orbits (p=0.002). The age at operation was significantly negatively correlated with orbital volume difference (p=0.033). Orbital volume differences for children treated by enucleation before the age of 12 months were also statistically significantly larger than those treated later. (p=0.03). CONCLUSION: Significant orbital growth retardation remained after enucleation, even with a hydroxyapatite implant for the RB orbit. Orbital growth retardation was correlated with operation age and also more prominent in children treated in the first year of life.
机译：目的：通过基于CT成像测量眼眶体积，确定羟基磷灰石植入物摘除对视网膜母细胞瘤（RB）幸存者骨眶发育的影响。方法：作者使用中位年龄为6岁的CT图像来测量18例接受羟基磷灰石植入治疗RB的患者的RB的眼眶容积和对侧眼眶。使用Wilcoxon秩和检验比较了RB和对侧轨道的轨道体积。结果：诊断和手术的平均年龄为29 +/- 23个月，平均随访时间为49 +/- 31个月。 RB和对侧轨道之间的平均体积差为0.93 +/- 1.13 cm（3）。羟基磷灰石植入物的RB轨道在统计学上显着小于对侧轨道（p = 0.002）。手术年龄与眼眶容积差异显着负相关（p = 0.033）。从统计学上来说，在12个月之前进行摘除术治疗的儿童的眼眶容积差异也显着大于后来治疗的儿童。 （p = 0.03）。结论：去核后仍存在明显的眼眶发育迟缓，即使用RB植入羟基磷灰石也是如此。眼眶发育迟缓与手术年龄有关，在出生后第一年接受治疗的儿童中也更为明显。

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