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首页> 外文期刊>International Journal of Cardiology >Cataloguing the geometry of the human coronary arteries: a potential tool for predicting risk of coronary artery disease.
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Cataloguing the geometry of the human coronary arteries: a potential tool for predicting risk of coronary artery disease.

机译：对人类冠状动脉的几何结构进行分类：一种预测冠状动脉疾病风险的潜在工具。

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BACKGROUND: The non-uniform distribution of atherosclerosis in the human vasculature suggests that local fluid dynamics or wall mechanics may be involved in atherogenesis. Thus certain aspects of vascular geometry, which mediates both fluid dynamics and wall mechanics, might be risk factors for coronary atherosclerosis. Cataloguing the geometry of normal human coronary arteries and its variability is a first step toward identifying specific geometric features that increase vascular susceptibility to the disease. METHODS: Images of angiographically normal coronary arteries, including 32 left anterior descending (LAD) and 35 right coronary arteries (RCA), were acquired by clinical biplane cineangiography from 52 patients. The vessel axes in end diastole were reconstructed and geometric parameters that included measures of curvature, torsion and tortuosity were quantified for the proximal, middle and distal segments of the arteries. RESULTS: Statistical analysis shows that (1) in the LAD, curvature, torsion and tortuosity are generally highest in the distal portion, (2) in the RCA, these parameters are smallest in the middle segment, (3) the LAD exhibits significant higher torsion than the RCA (P < 0.005), and (4) >80% of the variability of coronary arterial geometry can be expressed in terms of two factors, one dominated by the curvature measures and tortuosity, and the other emphasizing the torsion parameters. CONCLUSIONS: This study has comprehensively documented the normal arterial geometry of the LAD and RCA in end diastole. This information may be used to guide the identification of geometric features that might be atherogenic risk factors.
机译：背景：动脉粥样硬化在人类脉管系统中的不均匀分布表明局部流体动力学或壁力学可能参与动脉粥样硬化的形成。因此，介导流体动力学和壁力学的血管几何学的某些方面可能是冠状动脉粥样硬化的危险因素。对正常人冠状动脉的几何形状及其变异性进行分类是确定增加血管对疾病易感性的特定几何特征的第一步。方法：通过临床双平面血管造影术从52例患者中获得了包括32例左前降支（LAD）和35例右冠状动脉（RCA）在内的正常的冠状动脉造影图像。重建舒张末期的血管轴，并量化动脉的近端，中间和远端部分的几何参数，包括曲率，扭曲和弯曲度。结果：统计分析表明，（1）在LAD中，远端的曲率，扭转和曲折通常最高，（2）在RCA中，这些参数在中间段最小，（3）LAD表现出较高的扭转力比RCA（P <0.005）和（4）> 80％的冠状动脉几何变异性可以用两个因素来表示，一个由弯曲度和弯曲度决定，另一个则强调扭转参数。结论：本研究全面记录了舒张末期LAD和RCA的正常动脉几何形状。该信息可用于指导识别可能是致动脉粥样硬化危险因素的几何特征。

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