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首页> 外文期刊>International Journal of Cardiology >Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome
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Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome

机译:丹参酮IIA磺酸钠通过NLRP3炎症小体改善了Beagle犬缺血性心肌炎和脂质蓄积

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摘要

Background: The activation of NOD-like receptor (NLR) family, pyrin-domain containing 3 (NLRP3) inflammasome has now been proven to have a close connection with myocardial ischemia (MI) during acute phase, but the mechanisms are not completely clear. This study investigated the role of NLRP3 inflammasome in pathogenesis of MI injury including inflammation and lipid accumulation, as well as the effects of sodium tanshinone IIA sulfonate (STS) and diltiazem hydrochloride (DI).
机译:背景:现已证明,NOD样受体(NLR)家族的激活,含有3个PINR域的炎性小体,在急性期与心肌缺血(MI)密切相关,但机制尚不完全清楚。这项研究调查了NLRP3炎性体在MI损伤的发病机理中的作用,包括炎症和脂质蓄积,以及丹参酮IIA磺酸钠(STS)和盐酸地尔硫卓(DI)的作用。

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