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Metabolic regulation of immune responses: therapeutic opportunities

机译:免疫反应的代谢调节:治疗机会

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摘要

Immune cell metabolism is dynamically regulated in parallel with the substantial changes in cellular function that accompany immune cell activation. While these changes in metabolism are important for facilitating the increased energetic and biosynthetic demands of activated cells, immune cell metabolism also has direct roles in controlling the functions of immune cells and shaping the immune response. A theme is emerging wherein nutrients, metabolic enzymes, and metabolites can act as an extension of the established immune signal transduction pathways, thereby adding an extra layer of complexity to the regulation of immunity. This Review will outline the metabolic configurations adopted by different immune cell subsets, describe the emerging roles for metabolic enzymes and metabolites in the control of immune cell function, and discuss the therapeutic implications of this emerging immune regulatory axis.
机译:免疫细胞代谢与伴随免疫细胞激活的细胞功能发生重大变化而动态调节。虽然这些新陈代谢的变化对于促进活化细胞增加的能量和生物合成需求很重要,但免疫细胞代谢在控制免疫细胞的功能和塑造免疫反应方面也有直接作用。一个主题正在出现,其中营养物质、代谢酶和代谢物可以作为已建立的免疫信号转导途径的延伸,从而为免疫调节增加额外的复杂性。本文将概述不同免疫细胞亚群采用的代谢构型,描述代谢酶和代谢物在控制免疫细胞功能中的新兴作用,并讨论这一新兴免疫调节轴的治疗意义。

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