The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+-ATPase subunit Vma7p

Eck R; Nguyen M; Gunther J; Kunkel W; Zipfel PF

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The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+-ATPase subunit Vma7p

机译：人类致病性酵母白色念珠菌的磷脂酰肌醇3-激酶Vps34p是一种多功能蛋白质，可与假定的液泡H + -ATPase亚基Vma7p相互作用

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The phosphatidylinositol 3-kinase Vps34p of Candida albicans participates in protein transport and in virulence. In order to characterize the functional link between these two activities we searched for proteins interacting with C albicans Vps34p and demonstrate physical interaction of Vps34p with the subunit of the vacuolar H+-ATPase Vma7p. The interaction initially observed in a yeast two-hybrid system was confirmed in vitro with recombinant proteins. Functional assays show that the Vps34p protein is necessary for vacuolar acidification and growth at alkaline pH. In addition, the vps34 null mutant of C albicans shows defective autophagocytosis. The relevance of these functions for virulence of C albicans is discussed. (c) 2005 Elsevier GmbH. All rights reserved.

机译：白色念珠菌的磷脂酰肌醇3-激酶Vps34p参与蛋白质的运输和毒力。为了表征这两个活动之间的功能联系，我们搜索了与白色念珠菌Vps34p相互作用的蛋白质，并证明了Vps34p与液泡H + -ATPase Vma7p的亚基的物理相互作用。最初在酵母双杂交系统中观察到的相互作用已在体外用重组蛋白得以证实。功能测定表明，Vps34p蛋白是液泡酸化和在碱性pH值下生长所必需的。此外，白色念珠菌的vps34空突变体显示出缺陷的自噬作用。讨论了这些功能与白色念珠菌毒力的相关性。（c）2005 Elsevier GmbH。版权所有。

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《International journal of medical microbiology: IJMM》 |2005年第1期|共10页
作者
Eck R; Nguyen M; Gunther J; Kunkel W; Zipfel PF;
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正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
Candida albicans; PtdIns 3-kinase; Vps34p; V-ATPase; Vma7p; SACCHAROMYCES-CEREVISIAE; 14-KDA SUBUNIT; GENE ENCODES; HOST STRAIN; IDENTIFICATION; ACIDIFICATION; CONSTRUCTION; ENDOCYTOSIS; VIRULENCE; MUTANTS;

机译：白色念珠菌;PtdIns 3-激酶;Vps34p;V-ATPase;Vma7p;糖酵母-酿酒酵母;14-KDA亚基;基因编码;寄主菌株;鉴定;鉴定;结构;内毒素;毒力;突变;

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1. The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+-ATPase subunit Vma7p [J] . Eck R, Nguyen M, Gunther J, International journal of medical microbiology: IJMM . 2005,第1期

机译：人类致病性酵母白色念珠菌的磷脂酰肌醇3-激酶Vps34p是一种多功能蛋白质，可与假定的液泡H + -ATPase亚基Vma7p相互作用
2. Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans [J] . Juliane Günther, Monika Nguyen, Albert H?rtl, Microbiology . 2005,第1期

机译：脂质激酶缺陷的磷脂酰肌醇3-激酶VPS34P的体内表征在念珠菌缺陷症中的生成和功能
3. A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. [J] . K Zhou, K Takegawa, S D Emr, Molecular and Cellular Biology . 1995,第10期

机译：盘基网柄菌中的磷脂酰肌醇（PI）激酶基因家族：推定的哺乳动物p110和酵母Vps34p PI 3-激酶同系物在生长和发育过程中的生物学作用。
4. Cell Wall (Surface) Proteome of Pathogenic Yeast Candida albicans Profiled by Chemical Labeling and LC-MS [C] . Jiang Qian, Jim E. Cutler, Richard B. Cole, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：细胞壁（表面）致病酵母念珠菌蛋白质组化学标签和LC-MS的蛋白质
5. Functional analysis of the CCAAT-box binding factor subunit Hap5p in the pathogenic yeast Candida albicans [D] . Johnson, Duncan Campbell 2006

机译：致病性酵母白色念珠菌中CCAAT-box结合因子亚基Hap5p的功能分析
6. A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. [O] . K Zhou, K Takegawa, S D Emr, 1995

机译：盘基网柄菌中的磷脂酰肌醇（PI）激酶基因家族：假定的哺乳动物p110和酵母Vps34p PI 3-激酶同系物在生长和发育过程中的生物学作用。
7. A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. [O] . Zhou, K, Takegawa, K, Emr, S D, 1995

机译：盘基网柄菌中的磷脂酰肌醇（PI）激酶基因家族：假定的哺乳动物p110和酵母Vps34p PI 3-激酶同系物在生长和发育过程中的生物学作用。
8. Isolation of Proteins Interacting With the Cyclin D1-CDK6 Complex From Normal and Tumorigenic Human Breast Cells Using a Novel Yeast Three-Hybrid System [R] . Nichols, M. A. , Xiong, Y. 1999

机译：使用新型酵母三杂交系统分离与正常和致瘤人乳腺细胞中的细胞周期蛋白D1-CDK6复合物相互作用的蛋白质

The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+-ATPase subunit Vma7p

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