Rational design of vaccines against tuberculosis directed by basic immunology

Reece ST; Kaufmann SHE

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Rational design of vaccines against tuberculosis directed by basic immunology

机译：通过基本免疫学指导合理设计抗结核疫苗

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Tuberculosis represents a serious problem for public health worldwide, and effective vaccines are urgently required. This represents a significant challenge as the causative bacterial agent, Mycobacterium tuberculosis, has developed strategies to persist in infected hosts despite the presence of potent T-cell-mediated immune responses. New advances in basic immunology are giving us improved understanding of what constitutes a protective immune response and ways this response is manipulated by the bacillus. Such insights should inform us how to design more effective vaccination strategies against intracellular pathogens. (C) 2007 Elsevier GmbH. All rights reserved.

机译：结核病是全世界公共卫生的严重问题，迫切需要有效的疫苗。这是一个重大挑战，因为致病细菌病原体结核分枝杆菌已开发出可以在受感染宿主中持久存在的策略，尽管存在有效的T细胞介导的免疫反应。基础免疫学的新进展使我们对构成保护性免疫反应的成分以及细菌对这种反应的控制方式有了更深入的了解。这样的见解应该告诉我们如何设计针对细胞内病原体的更有效的疫苗接种策略。（C）2007 Elsevier GmbH。版权所有。

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《International journal of medical microbiology: IJMM》 |2008年第2期|共8页
作者
Reece ST; Kaufmann SHE;
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正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
tuberculosis; vaccine; BCG; immunity; T-CELL RESPONSES; BACILLUS-CALMETTE-GUERIN; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; MACROPHAGE APOPTOSIS; PROTECTIVE EFFICACY; INTERFERON-GAMMA; SUBUNIT VACCINE; INFECTION; BCG;

机译：结核病;疫苗;BCG;免疫;T细胞反应;杆菌-钙-球蛋白;结核分枝杆菌;李斯特菌-单核细胞增生;巨噬细胞凋亡;保护功效;干扰素γ;亚单位疫苗;感染;

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1. Rational design of vaccines against tuberculosis directed by basic immunology [J] . Reece ST, Kaufmann SHE International journal of medical microbiology: IJMM . 2008,第1a2期

机译：通过基本免疫学指导合理设计抗结核疫苗
2. A decade of vaccines: Integrating immunology and vaccinology for rational vaccine design. [J] . DArgenio DA, Wilson CB Immunity . 2010,第4期

机译：疫苗十年：将免疫学和疫苗学相结合以进行合理的疫苗设计。
3. A decade of vaccines: Integrating immunology and vaccinology for rational vaccine design. [J] . DArgenio DA, Wilson CB Immunity . 2010,第4期

机译：疫苗十年：将免疫学和疫苗学相结合以进行合理的疫苗设计。
4. SARS Vaccine Rational Vaccine Design and Construction [C] . . -1

机译：SARS疫苗合理疫苗的设计与施工
5. Immunology of BCG vaccination in mice: Implications for tuberculosis vaccination and for the use of BCG as a recombinant vaccine vector. [D] . Power, Carl Andrew. 2000

机译：小鼠BCG疫苗接种的免疫学：对结核疫苗的接种以及BCG作为重组疫苗载体的用途。
6. Host response to tuberculosis as basis for rational design of vaccines and biomarkers [O] . Stefan HE Kaufmann 2010

机译：宿主对结核病的反应作为合理设计疫苗和生物标志物的基础
7. A Decade of Vaccines: Integrating Immunology and Vaccinology for Rational Vaccine Design [O] . DArgenio David A., Wilson Christopher B. 2010

机译：疫苗十年：将免疫学和疫苗学相结合以进行合理的疫苗设计
8. Development of a Medical Research Institute Directed At Basic and Clinical Research Immunology. [R] . Henderson, L., Hall, R. 1992

机译：开发指导基础和临床研究免疫学的医学研究所。

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Rational design of vaccines against tuberculosis directed by basic immunology

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