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Evolution of pathogenicity islands of Salmonella enterica

机译:肠沙门氏菌致病岛的演变

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Virulence genes located on pathogenicity islands play a crucial role in the pathogenesis of Salmonella enterica infections. Salmonella pathogenicity islands (SPI) contribute to host cell invasion and intracellular pathogenesis. At present, 12 SPI have been described. Although size, structure and function of these SPI, as well as the distribution in Salmonella subspecies and serovars can be markedly different, several common motifs are present among SPI. In this review, the characteristics of SPI are described with focus on the evolution of these genetic elements. (C) 2004 Elsevier GmbH. All rights reserved.
机译:位于致病岛上的毒力基因在肠沙门氏菌感染的发病机理中起着至关重要的作用。沙门氏菌致病岛(SPI)有助于宿主细胞入侵和细胞内发病机理。目前,已经描述了12个SPI。尽管这些SPI的大小,结构和功能,以及沙门氏菌亚种和血清型的分布可能存在明显差异,但SPI中存在一些常见的基序。在这篇综述中,SPI的特征以这些遗传元件的进化为重点进行了描述。 (C)2004 Elsevier GmbH。版权所有。

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