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首页> 外文期刊>International Journal of Leprosy and Other Mycobacterial Diseases >HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy.
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HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy.

机译：中国南部的HLA与麻风病相关：HLA与麻风病相关的抗性等位基因。

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摘要

According to the World Health Organization recommended multidrug therapy (WHO/MDT), we have carried out this study to investigate the presence of HLA-linked susceptibility or resistance to leprosy in a southern Chinese population. Sixty-nine leprosy patients and 112 healthy controls participated in the study. HLA-DR2 subtypes, HLA-B and MHC Class I chain-related A (MICA) alleles were typed at the DNA level using the polymerase chain reaction-single strand conformation polymorphism method. The frequencies of HLA-DR2-DRB1 alleles did not show any significant differences between the patient and the control groups, suggesting that the disease susceptibility was not associated with the DR2 subtypes in this southern Chinese population. On the other hand, in the multibacillary (MB) patients significantly decreased allele frequencies of HLA-B46 (0.040 in MB patients vs 0.129 in controls) and MICA-A5 (0.200 vs 0.380) were observed compared with the healthy controls. The calculated relative risk (RR) for B46 was 0.28; for MICA-A5, 0.52. In addition, on haplotype analysis the frequency of the HLA-B46/MICA-A5 haplotype was significantly decreased in the MB patients compared to controls (0.060 vs 0.233, RR = 0.22, p < 0.01). These results suggest that an HLA-linked disease-resistant gene to MB leprosy in southern China is in strong linkage disequilibrium with the HLA-B46/MICA-A5 haplotype. In other words, the resistant gene may be located near the HLA-B/MICA region and not in the HLA-DR locus.
机译：根据世界卫生组织推荐的多药疗法（WHO / MDT），我们进行了这项研究，以调查在华南地区人群中HLA关联的对麻风病的易感性或耐药性。六十九名麻风病患者和112名健康对照参加了这项研究。使用聚合酶链反应-单链构象多态性方法在DNA水平上对HLA-DR2亚型，HLA-B和MHC I类链相关的A（MICA）等位基因进行分型。 HLA-DR2-DRB1等位基因的频率在患者和对照组之间没有显示任何显着差异，这表明该华裔人群的疾病易感性与DR2亚型无关。另一方面，与健康对照组相比，在多细菌性（MB）患者中观察到HLA-B46等位基因频率显着降低（MB患者为0.040，对照组为0.129）和MICA-A5（0.200对，0.380）。计算出的B46相对危险度（RR）为0.28;对于MICA-A5，为0.52。此外，在单倍型分析中，MB患者与对照组相比，HLA-B46 / MICA-A5单倍型的频率显着降低（0.060 vs 0.233，RR = 0.22，p <0.01）。这些结果表明，在中国南部，与麻风病有关的HLA连锁抗病基因与HLA-B46 / MICA-A5单倍型之间存在强连锁不平衡。换句话说，抗性基因可以位于HLA-B / MICA区域附近而不在HLA-DR基因座中。

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