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首页> 外文期刊>International journal of medical microbiology: IJMM >Hierarchical gene regulators adapt Salmonella enterica to its host milieus
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Hierarchical gene regulators adapt Salmonella enterica to its host milieus

机译：分级基因调节剂使肠沙门氏菌适应其宿主环境

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摘要

The facultative intracellular pathogen Salmonella enterica serovar Typhimurium possesses an elaborate set of virulence genes that enables the bacterium successfully to move between and adapt to the environment, different host organisms and various micro-niches within a given host. Expression of virulence attributes is by no means constitutive. Rather, the regulation of virulence determinants is highly coordinated and integrated into normal bacterial physiological responses. By integrating discriminating virulence gene regulators with conserved housekeeping regulatory processes, the bacteria can sense alterations in the repertoire of environmental cues, and translate the sensing events into a pragmatic and coordinated expression of virulence genes. While the description of transmissible genetic elements that import global gene regulatory factors into a cell brings conceptual problems into the established regulatory network, the existence of mobile gene regulators may actually enable the bacteria to further modulate virulence expression. (c) 2004 Elsevier GmbH. All rights reserved.
机译：兼性的细胞内病原体肠炎沙门氏菌鼠伤寒沙门氏菌具有一套精心设计的毒力基因，能够使细菌成功地在环境，不同宿主生物和给定宿主内的各种小生境之间移动并适应环境。毒力属性的表达绝不是构成性的。相反，毒力决定因素的调节高度协调并整合到正常细菌的生理反应中。通过将区分性毒力基因调节剂与保守的内务管理过程相结合，细菌可以感知环境提示的种类变化，并将感测事件转化为实用且协调的毒力基因表达。虽然将全局基因调控因子导入细胞的可传播遗传元件的描述将概念性问题引入已建立的调控网络，但流动基因调控器的存在实际上可能使细菌能够进一步调控毒力表达。 （c）2004 Elsevier GmbH。版权所有。

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